Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Sci Rep. 2023 May 9;13(1):7495. doi: 10.1038/s41598-023-33782-z.
A uniform prognostic marker is needed for nontuberculous mycobacterial pulmonary disease (NTM-PD) due to the diverse clinical course. We aimed to seek the utility of the BACES score, originally derived to predict all-cause mortality, for various outcomes. To calculate the BACES score, one point was given for each of the following factors: body mass index < 18.5 kg/m, age ≥ 65 years, presence of cavities, elevated erythrocyte sedimentation rate, or male sex. The study included 681 patients, of whom 97 (14.2%), 189 (27.7%), 192 (28.2%), 143 (21.0%), 47 (6.9%), and 13 (1.9%) had BACES scores of 0 to 5. Those with greater BACES scores were more likely to experience dyspnea, body weight loss, and anorexia. With severe disease, the risk of disease progression increased while the rate of treatment culture conversion decreased. After adjustment of comorbidities, higher BACES score was independently associated with the risk of mortality from respiratory causes or infection. As a simple and efficient bedside tool for assessing the severity of NTM-PD, the BACES score has the potential to be utilized as a surrogate marker for uniform severity assessment.
由于非结核分枝杆菌肺病（NTM-PD）的临床病程多样，因此需要一个统一的预后标志物。我们旨在寻找 BACES 评分的实用性，该评分最初用于预测全因死亡率，以用于各种结局。计算 BACES 评分时，以下每个因素各计 1 分：体重指数 <18.5 kg/m2、年龄 ≥65 岁、有空洞、红细胞沉降率升高或男性。该研究纳入了 681 名患者，其中 97 名（14.2%）、189 名（27.7%）、192 名（28.2%）、143 名（21.0%）、47 名（6.9%）和 13 名（1.9%）的 BACES 评分为 0 至 5。评分较高的患者更有可能出现呼吸困难、体重减轻和食欲不振。随着疾病的严重程度增加，疾病进展的风险增加，而治疗培养转化率降低。在调整合并症后，较高的 BACES 评分与呼吸原因或感染导致的死亡风险独立相关。作为一种简单有效的床边工具，用于评估 NTM-PD 的严重程度，BACES 评分有可能作为统一严重程度评估的替代标志物。
