Park Youngmok, Kwak Nakwon, Hwang Hyeontaek, Jeon Doosoo, Jhun Byung Woo, Jo Kyung-Wook, Kang Young Ae, Kim Hyung-Jun, Kim Joong-Yub, Kim Young Ran, Kwon Yong-Soo, Lee Jae Ho, Shim Tae Sun, Sohn Hojoon, Whang Jake, Kim Jayoun, Park Nanhee, Lee Gyeong In, Yim Jae-Joon, Mok Jeongha
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Institute for Innovation in Digital Healthcare, Yonsei University, Seoul, Republic of Korea.
Sci Rep. 2025 Jul 19;15(1):26257. doi: 10.1038/s41598-025-09971-3.
The evaluation of health-related quality of life (HRQOL) is gaining importance among patients with nontuberculous mycobacterial pulmonary disease (NTM-PD). We assessed whether the BACES score reflects HRQOL and associated factors in these patients. Data were collected from the nationwide NTM-KOREA prospective cohort of patients with NTM-PD who started antibiotic treatment and included symptoms, Quality of Life-Bronchiectasis (QOL-B) questionnaire, nutritional status using the Mini Nutritional Assessment-Short Form (MNA-SF) and Prognostic Nutritional Index (PNI), physical activity, body composition, spirometry, handgrip strength, and 6-min walking distance. Multivariate linear and logistic regressions were used for analysis. As the BACES score increased, so did the odds (adjusted odds ratio [95% confidence interval]) of cough (1.24 [1.04-1.48]), dyspnea (1.69 [1.28-2.27]), weight loss (1.78 [1.36-2.36]), and malnutrition, defined as MNA-SF score ≤ 7 (1.71 [1.21-2.45]), and PNI < 45 (2.14 [1.66-2.81]). The QOL-B respiratory symptom score (estimate: -2.259, P = 0.002) and 6-min walking distance (estimate: -18.015, P < 0.001) were negatively associated with the BACES score. Moreover, the odds of adipopenia (1.08 [1.03-1.13]), possible sarcopenia (1.80 [1.35-2.45]), and sarcopenia (2.09 [1.48-3.03]) increased in women. The BACES score can estimate HRQOL and associated conditions at antimicrobial treatment initiation in patients with NTM-PD.
在非结核分枝杆菌肺病（NTM-PD）患者中，与健康相关的生活质量（HRQOL）评估正变得越来越重要。我们评估了BACES评分是否能反映这些患者的HRQOL及相关因素。数据收集自全国性的NTM-韩国前瞻性队列中开始抗生素治疗的NTM-PD患者，包括症状、支气管扩张症生活质量（QOL-B）问卷、使用微型营养评定简表（MNA-SF）和预后营养指数（PNI）评估的营养状况、身体活动、身体成分、肺功能测定、握力和6分钟步行距离。采用多变量线性和逻辑回归进行分析。随着BACES评分升高，咳嗽（调整优势比[95%置信区间]为1.24[1.04 - 1.48]）、呼吸困难（1.69[1.28 - 2.27]）、体重减轻（1.78[1.36 - 2.36]）以及定义为MNA-SF评分≤7（1.71[1.21 - 2.45]）和PNI<45（2.14[1.66 - 2.81]）的营养不良的发生几率也增加。QOL-B呼吸症状评分（估计值：-2.259, P = 0.002）和6分钟步行距离（估计值：-18.015, P < 0.001）与BACES评分呈负相关。此外，女性中脂肪减少（1.08[1.03 - 1.13]）、可能的肌肉减少症（1.80[1.35 - 2.45]）和肌肉减少症（2.09[1.48 - 3.03]）的发生几率增加。BACES评分可在NTM-PD患者开始抗菌治疗时评估HRQOL及相关状况。
