Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Int J Tuberc Lung Dis. 2023 Jun 1;27(6):465-470. doi: 10.5588/ijtld.22.0616.
The severity of non-tuberculous mycobacterial pulmonary disease (NTM-PD) can be classified based on an assessment of the patient´s body mass index, age, presence of cavity, erythrocyte sediment rate and sex (BACES). In this study, changes in lung function according to disease severity were analysed. Patients with NTM-PD who underwent at least two lung function tests between 1 January 2011 and 31 December 2021, were classified according to their BACES score into mild (0-1), moderate (2-3) and severe (4-5) groups, and changes in lung function were assessed using BACES scores. A total of 354 patients were divided into three groups: mild ( = 108), moderate ( = 216) and severe ( = 30). As disease severity increased, the decrease in forced expiratory volume in 1 sec (FEV), forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DL) was greater: respectively 26.4 mL/year, 31.3 mL/year and 35.7 mL/year in case of FEV ( for trend = 0.002); 18.9 mL/year, 25.5 mL/year and 48.9 mL/year in case of FVC ( for trend = 0.002); and 0.7%/year, 1.3%/year and 2.5%/year for DL ( for trend = 0.023) in the mild, moderate and severe groups. The decrease in lung function in NTM-PD was correlated with disease severity.
非结核分枝杆菌肺病（NTM-PD）的严重程度可以根据患者的体重指数、年龄、空洞存在情况、红细胞沉降率和性别（BACES）进行评估。本研究分析了根据疾病严重程度的肺功能变化。2011 年 1 月 1 日至 2021 年 12 月 31 日期间至少进行了两次肺功能检查的 NTM-PD 患者，根据 BACES 评分分为轻度（0-1）、中度（2-3）和重度（4-5）组，并用 BACES 评分评估肺功能变化。共 354 例患者分为三组：轻度（n=108）、中度（n=216）和重度（n=30）。随着疾病严重程度的增加，1 秒用力呼气量（FEV1）、用力肺活量（FVC）和一氧化碳弥散量（DLCO）的下降幅度更大：FEV1 分别为 26.4mL/年、31.3mL/年和 35.7mL/年（趋势=0.002）；FVC 分别为 18.9mL/年、25.5mL/年和 48.9mL/年（趋势=0.002）；DLCO 分别为 0.7%/年、1.3%/年和 2.5%/年（趋势=0.023）。NTM-PD 患者的肺功能下降与疾病严重程度相关。
