Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
Hypertens Res. 2023 Jul;46(7):1795-1803. doi: 10.1038/s41440-023-01301-2. Epub 2023 May 9.
Sodium-glucose cotransporter 2 (SGLT2) inhibitors lowers blood pressure (BP) and exert a salutary effect on the salt sensitivity of BP. This study aimed to examine the associations of SGLT2 genetic variants with salt sensitivity, longitudinal BP changes and the risk of incident hypertension in Baoji Salt-Sensitive Study. A total of 514 participants were recruited when the cohort was established in 2004, and 333 participants received a dietary intervention that consisted of a 3-day usual diet followed sequentially by a 7-day low-salt diet and a 7-day high-salt diet. The cohort was then followed up for 14 years to evaluate the longitudinal BP changes and development of hypertension. We found that SGLT2 SNP rs3813007 was significantly associated with the systolic BP (SBP) responses to the low-salt diet. Over the 14 years of follow-up, SNPs rs3116149 and rs3813008 were significantly associated with the longitudinal SBP changes, and SNPs rs3116149, rs3813008, rs3813007 in SGLT2 were significantly associated with incidence of hypertension. Furthermore, gene-based analyses revealed that SGLT2 was significantly associated with hypertension incidence. Our study suggests that SGLT2 genetic polymorphisms may be involved in salt sensitivity and development of hypertension.
钠-葡萄糖共转运蛋白 2（SGLT2）抑制剂可降低血压（BP），并对 BP 的盐敏感性产生有益影响。本研究旨在探讨 SGLT2 基因变异与盐敏感性、纵向血压变化和宝鸡盐敏感研究中高血压发病风险的相关性。该队列于 2004 年建立时共招募了 514 名参与者，其中 333 名参与者接受了饮食干预，包括 3 天的常规饮食，随后依次进行 7 天低盐饮食和 7 天高盐饮食。然后对该队列进行了 14 年的随访，以评估纵向血压变化和高血压的发展情况。我们发现 SGLT2 SNP rs3813007 与低盐饮食对收缩压（SBP）的反应显著相关。在 14 年的随访期间，SNP rs3116149 和 rs3813008 与纵向 SBP 变化显著相关，SGLT2 中的 SNPs rs3116149、rs3813008 和 rs3813007 与高血压发病显著相关。此外，基于基因的分析表明 SGLT2 与高血压发病显著相关。我们的研究表明，SGLT2 基因多态性可能与盐敏感性和高血压的发生有关。
