Song Youhyun, Choi Ja-Eun, Park Jae-Min, Kwon Yu-Jin, Hong Kyung-Won, Lee Ji-Won
Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea.
Healthcare Research Team, Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea.
Nutrients. 2024 Nov 29;16(23):4147. doi: 10.3390/nu16234147.
There is limited evidence on gene-nutrient interaction associated with hypertension (HTN). We examined interactions between genotypes and various nutrients that influenced high blood pressure (BP). Data were obtained from a total of 50,808 participants from the Korean Genome and Epidemiology Study (KoGES). Dietary intake was assessed by a food frequency questionnaire, and dietary reference intakes (DRIs) were set. We performed genome-wide association analyses (GWAS) and subsequent interaction analyses with genome-wide significant SNPs to identify genomic loci that interact with specific nutrients associated with HTN. We identified one locus near the CUB and Sushi Multiple Domains 1 (CSMD1) gene that showed interaction with dietary iron and vitamin B6 (Vit.B6) intake and significantly influenced HTN risk. Among the individuals consuming iron above DRI (9.5 mg/day for men, 9.25 mg/day for women), carriers of the rs13282715 minor allele (A) at 8p23.2 showed a lower risk of HTN than those who did not (odds ratio [OR] 0.723, 95% confidence interval [CI] (0.644-0.813), -value 4.858 × 10; interaction -value 1.336 × 10). Among the individuals consuming Vit.B6 above DRI (1.5 mg/day for men, 1.4 mg/day for women), carriers of the same variant rs13282715 minor allele (A) also showed a lower risk of HTN (OR 0.733, 95% CI 0.733 (0.656-0.819), -value 4.121 × 10; interaction -value 7.183 × 10). We identified a novel gene-nutrient interaction regarding dietary iron and Vit.B6 intake affecting the risk of HTN in Korean adults. This suggests individuals with the variant may benefit from lower HTN risk from dietary intervention of iron and Vit.B6 intake. Further studies with larger diverse populations are warranted to validate our findings.
关于与高血压（HTN）相关的基因 - 营养素相互作用的证据有限。我们研究了影响高血压（BP）的基因型与各种营养素之间的相互作用。数据来自韩国基因组与流行病学研究（KoGES）的总共50,808名参与者。通过食物频率问卷评估饮食摄入量，并设定膳食参考摄入量（DRIs）。我们进行了全基因组关联分析（GWAS）以及随后与全基因组显著单核苷酸多态性（SNPs）的相互作用分析，以确定与HTN相关的特定营养素相互作用的基因组位点。我们在CUB和寿司多结构域1（CSMD1）基因附近鉴定出一个位点，该位点显示出与膳食铁和维生素B6（Vit.B6）摄入量相互作用，并显著影响HTN风险。在铁摄入量高于DRI（男性为9.5毫克/天，女性为9.25毫克/天）的个体中，8p23.2处rs13282715次要等位基因（A）的携带者患HTN的风险低于未携带者（比值比[OR] 0.723，95％置信区间[CI]（0.644 - 0.813），P值4.858×10⁻⁵；相互作用P值1.336×10⁻²）。在维生素B6摄入量高于DRI（男性为1.5毫克/天，女性为1.4毫克/天）的个体中，相同变体rs13282715次要等位基因（A）的携带者也显示出较低的HTN风险（OR 0.733，95％CI 0.733（0.656 - 0.819），P值4.121×10⁻⁵；相互作用P值7.183×10⁻³）。我们确定了一种关于膳食铁和维生素B6摄入量影响韩国成年人HTN风险的新型基因 - 营养素相互作用。这表明具有该变体的个体可能从铁和维生素B6摄入量的膳食干预中降低HTN风险中受益。有必要对更多样化的人群进行进一步研究以验证我们的发现。
