First Department of Cardiology.
Department of Gastroenterology, University of Ioannina Faculty of Medicine, Ioannina, Greece.
Eur J Gastroenterol Hepatol. 2023 Jul 1;35(7):695-701. doi: 10.1097/MEG.0000000000002562. Epub 2023 May 8.
Atrial fibrillation is the most common arrhythmia in clinical practice and it is associated with increased morbidity and mortality. Atrial fibrillation is linked with inflammatory signaling while inflammation and oxidative stress promote atrial remodeling promoting the development and perpetuation of the arrhythmia. On the other hand, inflammatory bowel disease (IBD) is considered a chronic inflammatory condition with flares and remissions. IBD has been associated with an increased risk of atherosclerotic cardiovascular disease but its relationship with atrial fibrillation has not been studied well. Recent epidemiological evidence indicates an association between IBD and atrial fibrillation, especially during flares/hospitalizations. This brief review provides a concise overview of all available data regarding the association between IBD and atrial fibrillation including the predictive role of electrocardiographic and echocardiographic markers. Several unresolved issues including the thromboembolic risk in this setting and the potential role of antiinflammatory interventions are also discussed.
心房颤动是临床实践中最常见的心律失常，与发病率和死亡率的增加有关。心房颤动与炎症信号有关，而炎症和氧化应激促进心房重构，促进心律失常的发展和持续。另一方面，炎症性肠病（IBD）被认为是一种具有发作和缓解的慢性炎症性疾病。IBD 与动脉粥样硬化性心血管疾病的风险增加有关，但它与心房颤动的关系尚未得到很好的研究。最近的流行病学证据表明，IBD 与心房颤动之间存在关联，尤其是在发作/住院期间。本综述简要概述了关于 IBD 和心房颤动之间关联的所有现有数据，包括心电图和超声心动图标志物的预测作用。还讨论了一些尚未解决的问题，包括这种情况下的血栓栓塞风险以及抗炎干预的潜在作用。
