Goyal Aman, Jain Hritvik, Maheshwari Surabhi, Jain Jyoti, Odat Ramez M, Saeed Humza, Daoud Mohamed, Mahalwar Gauranga, Bansal Kamna
Department of Internal Medicine, Seth GS Medical College and KEM Hospital, Mumbai, India.
Department of Internal Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur, India.
Int J Cardiol Heart Vasc. 2024 Jul 25;53:101456. doi: 10.1016/j.ijcha.2024.101456. eCollection 2024 Aug.
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a prevalent condition associated with chronic noninfectious inflammation of the gastrointestinal tract. It has been hypothesized that chronic inflammation can predispose patients to atrial fibrillation (AF), however, no clear evidence exists to support this.
A systematic literature search was conducted using major databases aimed at studies focusing on AF development in patients with IBD. Further subgroup analyses were performed for ulcerative colitis (UC) and crohn's disease (CD). Risk ratios (RR) with their corresponding 95 % confidence intervals (CI) were pooled using a random-effects model in the Review Manager Software. Statistical significance was set at p < 0.05.
Seven studies with 88,893,407 patients were included (1,002,719 and 87, 890, 688 patients in the IBD and non-IBD groups, respectively). IBD patients were at an increased risk of developing AF [RR: 1.52; 95 % CI: 1.19-1.95; p = 0.0009] compared to the non-IBD group. In subgroup analyses, patients with UC were at an increased risk of developing AF [RR: 1.29; 95 % CI: 1.08-1.53; p = 0.004], as were CD patients [RR: 1.30; 95 % CI: 1.07-1.58; p = 0.008] compared to the non-UC and non-CD groups, respectively.
Patients with IBD are at nearly 1.5 times the risk of developing AF compared to the non-IBD population. Our -analysis was limited by heterogeneity among the studies, highlighting the importance of further large-scale prospective studies to establish more robust evidence.
炎症性肠病（IBD），包括克罗恩病（CD）和溃疡性结肠炎（UC），是一种与胃肠道慢性非感染性炎症相关的常见病症。据推测，慢性炎症可能使患者易患心房颤动（AF），然而，尚无明确证据支持这一点。
使用主要数据库进行系统文献检索，旨在研究IBD患者中AF的发生情况。对溃疡性结肠炎（UC）和克罗恩病（CD）进行了进一步的亚组分析。在Review Manager软件中使用随机效应模型汇总风险比（RR）及其相应的95%置信区间（CI）。设定统计学显著性为p < 0.05。
纳入了7项研究，共88,893,407例患者（IBD组和非IBD组分别为1,002,719例和87,890,688例）。与非IBD组相比，IBD患者发生AF的风险增加[RR：1.52；95%CI：1.19 - 1.95；p = 0.0009]。在亚组分析中，与非UC组和非CD组相比，UC患者发生AF的风险增加[RR：1.29；95%CI：1.08 - 1.53；p = 0.004]，CD患者发生AF的风险也增加[RR：1.30；95%CI：1.07 - 1.58；p = 0.008]。
与非IBD人群相比，IBD患者发生AF的风险几乎是非IBD人群的1.5倍。我们的分析受到研究间异质性的限制，这凸显了进一步开展大规模前瞻性研究以建立更有力证据的重要性。
