Beijing Laboratory of Biomedical Materials, Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, P. R. China.
Institute of Medical Technology, Peking University Health Science Center, Beijing, P. R. China.
J Periodontol. 2023 Feb;94(2):256-262. doi: 10.1002/JPER.21-0632. Epub 2022 Aug 12.
To establish whether life course adiposity, including birth weight (BW), childhood and adulthood body mass index (BMI), waist-hip ratio (WHR), and body fat percentage (BF%), has a causal influence on periodontitis.
We used single-nucleotide polymorphisms with significant associations with life course adiposity as instrumental variables. We examined their association with periodontitis risk in a genome-wide association study involving periodontitis cases (n = 17,353) and healthy controls (n = 28,210) using a two-sample Mendelian randomization (MR) strategy. The association of life course adiposity with periodontitis risk was estimated with inverse-variance weighting with random effects. We performed sensitivity analyses using MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), weighted median, and MR-Egger methods. We calculated the odds ratios (ORs) for one standard deviation (SD) increase per risk factor to estimate the effect on the risk of periodontitis.
After correction for multiple testing, there was an association between each SD increase in gene-predicted adulthood BMI with a higher periodontitis risk (OR = 1.15, 95% confidence interval [CI]: 1.06-1.23, p = 3.1 × 10), with a similar influence for BF% on periodontitis risk (OR = 1.29, 95% CI: 1.12-1.49, p = 3.3 × 10). No causal association was detected for gene-predicted BW, childhood BMI, or WHR with periodontitis risk.
We present new proof supporting a causal function of greater adiposity, especially high BMI and BF%, being associated with higher periodontitis risk. We recommend that future studies focus on periodontitis from a life course perspective.
为了确定生命历程中的肥胖程度，包括出生体重（BW）、儿童期和成年期的体重指数（BMI）、腰臀比（WHR）和体脂百分比（BF%），是否对牙周炎有因果影响。
我们使用与生命历程肥胖具有显著关联的单核苷酸多态性作为工具变量。我们使用两样本 Mendelian 随机化（MR）策略，在一项涉及牙周炎病例（n=17353）和健康对照（n=28210）的全基因组关联研究中，检查了它们与牙周炎风险的关联。使用逆方差加权和随机效应估计了生命历程肥胖与牙周炎风险的关联。我们使用 MR 多效性残余和异常值（MR-PRESSO）、加权中位数和 MR-Egger 方法进行敏感性分析。我们计算了每个风险因素增加一个标准差（SD）的比值比（OR），以估计对牙周炎风险的影响。
在多重检验校正后，基因预测的成年 BMI 每增加一个 SD 与更高的牙周炎风险相关（OR=1.15，95%置信区间[CI]：1.06-1.23，p=3.1×10），BF% 对牙周炎风险也有类似的影响（OR=1.29，95%CI：1.12-1.49，p=3.3×10）。基因预测的 BW、儿童期 BMI 或 WHR 与牙周炎风险之间未检测到因果关系。
我们提供了新的证据支持更大的肥胖程度，尤其是较高的 BMI 和 BF%，与更高的牙周炎风险之间存在因果关系。我们建议未来的研究从生命历程的角度关注牙周炎。
