维拉帕米对静息性不稳定型心绞痛的治疗。冠心病监护病房的双盲交叉研究。
Management of unstable angina at rest by verapamil. A double-blind cross-over study in coronary care unit.
作者信息
Parodi O, Maseri A, Simonetti I
出版信息
Br Heart J. 1979 Feb;41(2):167-74. doi: 10.1136/hrt.41.2.167.
Abstract
A therapeutic trial with verapamil, a calcium-antagonist drug, was performed in 12 patients admitted to our coronary care unit because of frequent daily attacks of angina at rest attributed to coronary vasospasm. After a 48-hour run-in period, oral verapamil 480 mg/day and placebo were administered alternately during 4 randomised 48-hour periods. Transient ischaemic attacks with ST segment elevation or depression, with or without pain, were documented by continuous electrocardiographic monitoring. The number of attacks during the run-in and 2 placebo periods were 128, 123, and 130, respectively, and 31 and 23 during the 2 treatment periods (P less than 0.006 and P less than 0.003). This drug therefore appears to be effective in the management of patients with frequent attacks of angina at rest.
摘要
对12名因冠状动脉痉挛导致每日频繁静息性心绞痛发作而入住我们冠心病监护病房的患者进行了一项使用钙拮抗剂药物维拉帕米的治疗试验。在48小时的导入期后，在4个随机的48小时时间段内交替给予口服维拉帕米480毫克/天和安慰剂。通过连续心电图监测记录伴有或不伴有疼痛的ST段抬高或压低的短暂性缺血发作。导入期和2个安慰剂期的发作次数分别为128次、123次和130次，2个治疗期分别为31次和23次（P<0.006和P<0.003）。因此，这种药物似乎对频繁发作静息性心绞痛的患者有效。
相似文献
1
Management of unstable angina at rest by verapamil. A double-blind cross-over study in coronary care unit.维拉帕米对静息性不稳定型心绞痛的治疗。冠心病监护病房的双盲交叉研究。
Br Heart J. 1979 Feb;41(2):167-74. doi: 10.1136/hrt.41.2.167.
2
Comparison of verapamil and propranolol therapy for angina pectoris at rest: a randomized, multiple-crossover, controlled trial in the coronary care unit.维拉帕米与普萘洛尔治疗静息性心绞痛的比较：冠心病监护病房的一项随机、多次交叉、对照试验
Am J Cardiol. 1986 Apr 15;57(11):899-906. doi: 10.1016/0002-9149(86)90727-7.
3
Effects of oral calcium-antagonists in spontaneous angina. Verapamil and nifedipine in a double-blind cross-over trial.
G Ital Cardiol. 1982;12(5):359-64.
4
Propranolol v. verapamil in the treatment of unstable angina. A double-blind cross-over study.普萘洛尔与维拉帕米治疗不稳定型心绞痛的对比研究。一项双盲交叉试验。
Eur Heart J. 1983 Mar;4(3):148-54. doi: 10.1093/oxfordjournals.eurheartj.a061434.
5
Verapamil therapy for unstable angina pectoris: review of double-blind placebo-controlled randomized clinical trials.维拉帕米治疗不稳定型心绞痛：双盲安慰剂对照随机临床试验综述
Am J Cardiol. 1982 Oct;50(4):919-22. doi: 10.1016/0002-9149(82)91254-1.
6
[Effectiveness of verapamil in the treatment of unstable angina at rest. Double-blind crossover studies in the coronary care unit].[维拉帕米治疗静息性不稳定型心绞痛的疗效。冠心病监护病房的双盲交叉研究]
Boll Soc Ital Cardiol. 1977;22(8):1331-41.
7
Comparison of nicardipine and verapamil in the management of chronic stable angina.
Int J Cardiol. 1988 Mar;18(3):357-69. doi: 10.1016/0167-5273(88)90054-x.
8
Calcium antagonist drugs in chronic stable angina. Comparison of verapamil and nifedipine.慢性稳定型心绞痛中的钙拮抗剂药物。维拉帕米与硝苯地平的比较。
Br Heart J. 1981 Nov;46(5):508-12. doi: 10.1136/hrt.46.5.508.
9
10
Verapamil for unstable angina at rest: a short-term randomized, double-blind study.
Am Heart J. 1983 Oct;106(4 Pt 1):652-8. doi: 10.1016/0002-8703(83)90082-0.
引用本文的文献
1
Coronary Microvascular Spasm: Clinical Presentation and Diagnosis.冠状动脉微血管痉挛：临床表现与诊断
Eur Cardiol. 2023 Mar 21;18:e07. doi: 10.15420/ecr.2022.50. eCollection 2023.
2
Verapamil and Alzheimer's Disease: Past, Present, and Future.维拉帕米与阿尔茨海默病：过去、现在与未来
Front Pharmacol. 2020 May 5;11:562. doi: 10.3389/fphar.2020.00562. eCollection 2020.
3
Verapamil and vasospastic angina: underuse in the elderly population.维拉帕米与变异性心绞痛：老年人群中的使用不足
J Geriatr Cardiol. 2017 Jul;14(7):430-435. doi: 10.11909/j.issn.1671-5411.2017.07.004.
4
Action of nifedipine in ischemic heart disease.硝苯地平在缺血性心脏病中的作用。
Can Fam Physician. 1983 Apr;29:703-8.
5
Pathogenetic mechanisms of angina pectoris: expanding views.心绞痛的发病机制：拓展观点
Br Heart J. 1980 Jun;43(6):648-60. doi: 10.1136/hrt.43.6.648.
6
Role of calcium antagonists in cardiovascular therapy.钙拮抗剂在心血管治疗中的作用。
Br Heart J. 1981 Jul;46(1):8-16. doi: 10.1136/hrt.46.1.8.
7
Comparison of antianginal actions of verapamil and propranolol.维拉帕米与普萘洛尔抗心绞痛作用的比较。
Br Med J (Clin Res Ed). 1981 May 30;282(6278):1754. doi: 10.1136/bmj.282.6278.1754.
8
Objective assessment of antianginal treatment: a double-blind comparison of propranolol, nifedipine, and their combination.抗心绞痛治疗的客观评估：普萘洛尔、硝苯地平及其联合用药的双盲比较。
Br Med J. 1980 Jul 19;281(6234):184-7. doi: 10.1136/bmj.281.6234.184.
9
Alterations in angina threshold with nifedipine during pacing induced angina.在起搏诱发心绞痛期间硝苯地平对心绞痛阈值的影响。
Br Heart J. 1984 Sep;52(3):308-13. doi: 10.1136/hrt.52.3.308.
10
Treatment of angina pectoris with nifedipine: importance of dose titration.硝苯地平治疗心绞痛：剂量滴定的重要性。
Br Med J (Clin Res Ed). 1983 May 7;286(6376):1467-70. doi: 10.1136/bmj.286.6376.1467.
本文引用的文献
1
Use of propranolol in preinfarction angina.普萘洛尔在梗死前心绞痛中的应用。
Circulation. 1971 Aug;44(2):303-4. doi: 10.1161/01.cir.44.2.303.
2
Left ventricular performance and related haemodynamic changes in Prinzmetal's variant angina pectoris.变异型心绞痛患者左心室功能及相关血流动力学变化
Br Heart J. 1971 Jan;33(1):84-94. doi: 10.1136/hrt.33.1.84.
3
4
5
Percutaneous transfemoral selective coronary arteriography.
Radiol Clin North Am. 1968 Dec;6(3):467-92.
6
Surgical management of Prinzmetal's variant angina.
Chest. 1974 Dec;66(6):614-21. doi: 10.1378/chest.66.6.614.
7
Unstable angina--prospective and randomized study of its evolution, with and without surgery.
Am J Cardiol. 1974 Feb;33(2):201-8. doi: 10.1016/0002-9149(74)90275-6.
8
Unstable angina pectoris: morbidity and mortality in 57 consecutive patients evaluated angiographically.不稳定型心绞痛：57例接受血管造影评估的连续患者的发病率和死亡率。
Am J Cardiol. 1973 Nov;32(6):745-50. doi: 10.1016/s0002-9149(73)80001-3.
9
Saphenous vein coronary artery bypass in patients with "preinfarction angina".
Circulation. 1973 Feb;47(2):234-41. doi: 10.1161/01.cir.47.2.234.
10
Coronary arterial spasm in Prinzmetal's angina: a proved hypothesis.变异型心绞痛中的冠状动脉痉挛：一个已证实的假说。
Am J Cardiol. 1976 May;37(6):938-40. doi: 10.1016/0002-9149(76)90124-7.
Zotero 插件