Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2023 May 10;13(1):7632. doi: 10.1038/s41598-023-34155-2.
Cancer is one of the important health problems in Iran, which is considered as the third cause of death. Endocrine cancers are rare but mostly curable. Thyroid cancer, the most common endocrine tumors, includes about one percent of malignant cancer. In this study, we examined the 15-year national trend of endocrine cancer incidence in Iranian men and women. The data in each province were evaluated based on age, gender, and cancer type according to International Classification of Disease Codes version 10 (ICD-10) from 2005 to 2020 in Iran. All data were obtained from the reports of the Statistics Center of Iran (SCI), 6 phases of the step-by-step approach to monitoring the risk factors of chronic diseases over 18 years old (STEPs), and 3 periods of the CASPIAN study (survey of non-communicable diseases in childhood and adolescence). Statistical analyzes and graph generation were done using R statistical software. Poisson regression with mixed effects was used for data modeling and incidence rate estimation. The incidence of thyroid gland malignancy is higher in women than in men. On the other hand, the incidence of adrenal gland cancer is slightly higher in men than in women. The same pattern is observed for other endocrine neoplasms and related structures. The incidence rate of these types of cancers has generally increased from 2005 to 2020 in Iran. This increase is more in women than in men. In addition, in the middle of the country, there is a strong region in terms of the occurrence of these types of cancers. The incidence rate in these provinces is relatively higher for both sexes and all studied periods. We conducted a study to observe the changing trends for various types of endocrine cancers over 15 years in men and women. Considering the increasing trend of thyroid cancers in Iran, therefore, creating essential policies for the management of these types of cancers for prevention, rapid diagnosis, and, timely treatment is particularly important.
癌症是伊朗的一个重要健康问题，也是导致死亡的第三大原因。内分泌癌较为罕见，但多数可治愈。甲状腺癌是最常见的内分泌肿瘤，约占恶性癌症的 1%。在这项研究中，我们检查了伊朗男性和女性 15 年内分泌癌发病率的国家趋势。根据国际疾病分类第十版（ICD-10），对伊朗 2005 年至 2020 年每个省的年龄、性别和癌症类型的数据进行了评估。所有数据均来自伊朗统计中心（SCI）的报告、6 期逐步监测 18 岁以上人群慢性病危险因素的方法（STEPs）和 3 期 CASPIAN 研究（儿童和青少年非传染性疾病调查）。统计分析和图形生成使用 R 统计软件完成。使用混合效应泊松回归进行数据建模和发病率估计。女性甲状腺恶性肿瘤的发病率高于男性。另一方面，肾上腺癌的发病率在男性中略高于女性。其他内分泌肿瘤和相关结构也观察到相同的模式。这些类型癌症的发病率自 2005 年至 2020 年在伊朗普遍呈上升趋势。女性的增幅高于男性。此外，在该国中部，这些类型癌症的发病率在某些地区较高。这些省份的发病率在两性和所有研究期间均相对较高。我们进行了一项研究，以观察 15 年来男女各种类型内分泌癌的变化趋势。考虑到伊朗甲状腺癌发病率的上升趋势，因此，制定有关这些类型癌症的管理政策，以进行预防、快速诊断和及时治疗尤为重要。
