Bulfamante Antonio Mario, Lori Eleonora, Bellini Maria Irene, Bolis Elisa, Lozza Paolo, Castellani Luca, Saibene Alberto Maria, Pipolo Carlotta, Fuccillo Emanuela, Rosso Cecilia, Felisati Giovanni, De Pasquale Loredana
Otolaryngology Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Milan, Italy.
Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
Front Oncol. 2022 Jul 7;12:954759. doi: 10.3389/fonc.2022.954759. eCollection 2022.
Differentiated thyroid cancers (DTCs) are slow-growing malignant tumours, including papillary and follicular carcinomas. Overall, prognosis is good, although it tends to worsen when local invasion occurs with bulky cervical nodes, or in the case of distant metastases. Surgery represents the main treatment for DTCs. However, radical excision is challenging and significant morbidity and functional loss can follow the treatment of the more advanced forms. Literature on advanced thyroid tumours, both differentiated and undifferentiated, does not provide clear and specific guidelines. This emerges the need for a tailored and multidisciplinary approach. In the present study, we report our single-centre experience of 111 advanced (local, regional, and distant) DTCs, investigating the rate of radical excision, peri-procedural and post-procedural complications, quality of life, persistence, recurrence rates, and survival rates. Results are critically appraised and compared to the existing published evidence review.
分化型甲状腺癌（DTC）是生长缓慢的恶性肿瘤，包括乳头状癌和滤泡状癌。总体而言，预后良好，不过当出现局部侵犯伴肿大的颈部淋巴结，或发生远处转移时，预后往往会变差。手术是DTC的主要治疗方法。然而，根治性切除具有挑战性，对于更晚期的病例，治疗后可能会出现明显的发病率和功能丧失。关于晚期甲状腺肿瘤（包括分化型和未分化型）的文献并未提供明确且具体的指南。这凸显了采用量身定制的多学科方法的必要性。在本研究中，我们报告了我们单中心对111例晚期（局部、区域和远处）DTC的经验，调查根治性切除率、围手术期和术后并发症、生活质量、持续存在率、复发率和生存率。对结果进行了严格评估，并与现有的已发表证据综述进行了比较。
