The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang East Road, Guangzhou, 510260, China.
Int J Clin Pharm. 2023 Aug;45(4):929-939. doi: 10.1007/s11096-023-01575-z. Epub 2023 May 11.
Poor pain control is common in perioperative orthopedic surgeries. However, there is a lack of exploration of the clinical pharmacy practice model for this population.
To construct a perioperative pharmaceutical care model and clinical pathway for patients undergoing orthopedic surgeries and assess their impact on pain management.
This historical before-and-after study was conducted in the Department of Orthopedics of a tertiary hospital in Guangdong Province, China. The control group was surgical patients who received routine diagnosis and treatment. The intervention group received pain management from a multidisciplinary team based on a pharmacist-initiated pharmaceutical care practice model and clinical pathways for medication management. The primary outcome measures were postoperative pain at rest (PAR) and movement-evoked pain (MEP) scores, number of breakthrough pains, and length of hospital stay.
A total of 320 orthopedic surgery patients were included. Among patients with expected moderate or severe postoperative pain (82.5%), significantly lower PAR and MEP scores were observed in the intervention group 24 h after surgeries compared to the control group (p < 0.05). Compared to the control group, hospital stay in the intervention group was shortened by 2.3 days (p < 0.001). However, there were no significant differences in the control of breakthrough pain and the incidence of adverse drug reactions (p > 0.05).
Multidisciplinary perioperative pain management practice models and clinical pathways initiated by pharmacists could improve outcome indicators related to pain management and support the role and value of pharmacists.
围手术期骨科手术中普遍存在疼痛控制不佳的情况。然而,对于这类人群,临床药学实践模式的探索还很缺乏。
构建骨科手术患者围手术期药学服务模式及临床路径,并评估其对疼痛管理的影响。
本研究为在中国广东省一家三级医院骨科进行的历史性前后对照研究。对照组为接受常规诊断和治疗的手术患者。干预组则在多学科团队的基础上,基于药师主导的药学服务实践模式和药物管理临床路径接受疼痛管理。主要结局指标为术后静息时疼痛(PAR)和运动诱发性疼痛(MEP)评分、爆发性疼痛的发生次数和住院时间。
共纳入 320 例骨科手术患者。在预计有中度或重度术后疼痛的患者(82.5%)中,与对照组相比,干预组术后 24 小时的 PAR 和 MEP 评分显著降低(p<0.05)。与对照组相比,干预组的住院时间缩短了 2.3 天(p<0.001)。然而,两组在爆发性疼痛的控制和药物不良反应的发生率方面无显著差异(p>0.05)。
由药师发起的多学科围手术期疼痛管理实践模式和临床路径可改善与疼痛管理相关的结局指标,并支持药师的作用和价值。