Gilde O, Schultz-Ehrenburg U
Z Hautkr. 1986 Apr 15;61(8):556-8.
E. cuniculatum is a low-grade squamous cell carcinoma belonging to the group of Ackerman's verrucous carcinoma. The papillomatous, cauliflower-like tumor slowly grows over many years without forming metastases. Histology reveals deeply invaginated proliferations with organoid epidermal organization and central parakeratotic horny crypts. Only the basal and suprabasal cell layers show histological features of malignancy; the basal membrane, however, remains intact. Radiation therapy as well as repeated operations may provoke anaplastic transformation into metastases. We discuss the therapy and differential diagnosis of these tumors and report on two own cases.
穴居艾氏癌是一种低级别鳞状细胞癌，属于阿克曼疣状癌组。这种乳头状、菜花状肿瘤多年来缓慢生长，不发生转移。组织学显示有深陷的增生，具有类器官表皮结构和中央不全角化角质隐窝。只有基底细胞层和基底上层细胞层显示恶性组织学特征；然而，基底膜保持完整。放射治疗以及反复手术可能会引发间变转化为转移瘤。我们讨论了这些肿瘤的治疗和鉴别诊断，并报告了两例我们自己的病例。
