Yue X H, Liu X M
Zhonghua Zhong Liu Za Zhi. 1986 May;8(3):219-21.
10 cases of verrucous carcinoma occurring in different sites were studied clinicopathologically. Clinically, the tumor grew slowly and presented as an ulcerous or cauliflower-like mass. The tumor, existing in the skin, had openings like the sinus tracts on the surface from which foul, grey and greasy material oozed out when pressured. There was no exudation if the lesion grew in the mucosa. Histologically, the tumor was composed of mature and well-differentiated squamous cells showing papilloma-like growth upwards, their epidermal rete showing spheroid expansions downwards. Prickle cell masses invaded into the soft tissue in the deeper layer. In view of the tumors having location either in the skin or mucosa with or without effusion, similar histologic features and biologic behavior, we suggest that the verrucous carcinoma and carcinoma cuniculatum be two different variants of the disease. Finally, its diagnosis, differential diagnosis and treatment are discussed with a review of the literature.
对10例发生于不同部位的疣状癌进行了临床病理研究。临床上，肿瘤生长缓慢，表现为溃疡性或菜花状肿块。肿瘤位于皮肤时，表面有类似窦道的开口，按压时会有恶臭、灰白色且油腻的物质渗出。如果病变发生在黏膜，则无渗出物。组织学上，肿瘤由成熟且分化良好的鳞状细胞组成，呈向上的乳头状生长，其表皮嵴向下呈球状扩张。棘细胞团侵入更深层的软组织。鉴于肿瘤位于皮肤或黏膜，有或无渗出，具有相似的组织学特征和生物学行为，我们认为疣状癌和漏斗状癌是该疾病的两种不同变体。最后，结合文献复习对其诊断、鉴别诊断及治疗进行了讨论。
