Department of Pharmacy, Nagano Chuo Hospital, Nagano City, Japan.
Department of Cardiology, Nagano Chuo Hospital, Nagano City, Japan.
BMC Infect Dis. 2023 May 10;23(1):316. doi: 10.1186/s12879-023-08293-x.
Campylobacter spp. is a gram-negative bacillus that causes infectious enteritis and consists of several species, including Campylobacter jejuni, Campylobacter coli, and Campylobacter fetus. Although C. jejuni and C. coli cause infectious enteritis primarily in immunocompetent hosts, C. fetus causes extraintestinal infections such as septicemia, meningitis, and perinatal infections in immunocompromised hosts, as well as myopericarditis in rare cases. Only a few cases of infectious myo(peri)carditis associated with C. coli in immunocompetent hosts have been reported. These studies concentrated on antecedent C. coli enterocolitis and never demonstrated a positive culture in the pericardial fluid.A 72-year-old Japanese man presented with a 2-week fever, cough, and vomiting lasting. He was on hemodialysis for polycystic kidney disease, as well as medication for diabetes and hypertension. A chest computed tomography (CT) scan and a transthoracic echocardiogram revealed bilateral pleural fluid and large pericardial fluid at the time of admission. C. coli was identified from blood culture samples and blood-tinged pericardial fluid. He was successfully treated with antibacterial chemotherapy as well as pericardial fluid drainage and was discharged from the hospital with no complications.In this case, the presence of C. coli in the pericardial fluid confirmed the diagnosis of C. coli pericarditis. C. coli may cause septic pericarditis in immunocompromised hosts, despite typically causing only enteritis.
空肠弯曲菌和大肠弯曲菌属革兰阴性杆菌,引起感染性肠炎,由多个种组成,包括空肠弯曲菌、大肠弯曲菌和胎儿弯曲菌。虽然空肠弯曲菌和大肠弯曲菌主要引起免疫功能正常宿主的感染性肠炎,但胎儿弯曲菌可引起免疫功能低下宿主的肠外感染,如败血症、脑膜炎和围生期感染,以及罕见情况下的心包心肌炎。仅有少数几例与免疫功能正常宿主中的大肠弯曲菌相关的感染性心(包)肌炎的报道。这些研究集中在大肠弯曲菌性肠炎的前期,从未在心包液中培养出阳性细菌。
一名 72 岁的日本男性,因发热、咳嗽和呕吐持续两周而就诊。他因多囊肾病接受血液透析,还在服用治疗糖尿病和高血压的药物。入院时,胸部计算机断层扫描(CT)和经胸超声心动图显示双侧胸腔积液和大量心包积液。从血液培养样本和血性心包液中鉴定出大肠弯曲菌。他成功地接受了抗菌化疗以及心包液引流治疗,出院时无并发症。
在本例中,心包液中存在大肠弯曲菌证实了大肠弯曲菌性心包炎的诊断。尽管大肠弯曲菌通常只引起肠炎,但它可引起免疫功能低下宿主的感染性化脓性心包炎。