Dysplastic nevus syndrome is an autosomally dominant disease, which may develop hereditary malignant melanoma. Dysplastic nevi are found anywhere on the body surface and show definite clinical characteristics. Histologic examination reveals atypical melanocytes at the dermo-epidermal junction and inflammatory infiltration in the dermis. The dysplastic cells show either lentiginous or epithelioid dysplasia. The evolution towards malignant melanoma always starts with the development of epithelioid melanocytes in the epidermis. Sunlight might further the mechanism of degeneration. Thus dysplastic nevus syndrome becomes important for the possible recognition and prevention of potential malignant melanoma.
发育异常痣综合征是一种常染色体显性疾病，可能发展为遗传性恶性黑色素瘤。发育异常痣可出现在体表任何部位，并具有明确的临床特征。组织学检查显示在真皮表皮交界处有非典型黑素细胞，真皮内有炎症浸润。发育异常细胞表现为雀斑样或上皮样发育异常。向恶性黑色素瘤的演变总是始于表皮中上皮样黑素细胞的发展。阳光可能会促进退变机制。因此，发育异常痣综合征对于潜在恶性黑色素瘤的可能识别和预防具有重要意义。
