Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.
Division of Nephrology and Hypertension, Department of Internal Medicine, College of Health, University of Utah, Salt Lake City, UT, USA.
Curr Med Chem. 2024;31(31):5083-5096. doi: 10.2174/0929867330666230509110111.
Circulating microRNAs (miRNAs) serve as noninvasive diagnostic markers in many cancers. This meta-analysis aims to evaluate the diagnostic efficacy of circulating microRNAs for melanoma.
The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and ROC curve were evaluated using the Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.3.3 software packages. To investigate the heterogeneity, the I and Chi-square tests were used. The publishing bias was evaluated using Begg's rank correlation and Egger regression asymmetry tests.
A total of 9 articles covering 13 studies (more than 50 miRs individually and in combination) were included, containing 1,355 participants (878 cases and 477 controls). The overall pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio (DOR), and AUC were 0.78 (95% CI: 0.76-0.81), 0.80 (95% CI: 0.77-0.83), 4.32 (95% CI: 3.21-5.82), 0.17 (95% CI: 0.09-0.32), 28.0 (95% CI: 15.34-51.09), and 0.91, respectively. According to Begg's and Egger's tests, there was no publication bias (Begg's p = 0.160 and Egger's p = 0.289).
Circulating miRNAs can serve as fair and non-invasive diagnostic biomarkers for melanoma. Additionally, specific miRNAs still need to be discovered for diagnosing melanoma.
循环 microRNAs（miRNAs）可作为许多癌症的非侵入性诊断标志物。本荟萃分析旨在评估循环 microRNAs 对黑色素瘤的诊断效能。
使用 Meta-Disc V.1.4 和 Comprehensive Meta-Analysis V.3.3 软件包评估合并后的敏感度、特异度、阳性似然比、阴性似然比、诊断优势比和 ROC 曲线。为了探究异质性，采用 I ² 和 Chi-square 检验。采用 Begg 秩相关和 Egger 回归不对称检验评估发表偏倚。
共纳入 9 项研究（单独和联合分析超过 50 个 miRNA），共纳入 13 项研究，包含 1355 名参与者（878 例病例和 477 例对照）。总体合并后的敏感度、特异度、阳性似然比、阴性似然比、诊断优势比和 AUC 分别为 0.78（95%CI：0.76-0.81）、0.80（95%CI：0.77-0.83）、4.32（95%CI：3.21-5.82）、0.17（95%CI：0.09-0.32）、28.0（95%CI：15.34-51.09）和 0.91。根据 Begg 和 Egger 检验，不存在发表偏倚（Begg p = 0.160，Egger p = 0.289）。
循环 miRNAs 可作为黑色素瘤的公平、非侵入性诊断生物标志物。此外，还需要发现特定的 miRNAs 来诊断黑色素瘤。
