淋巴细胞与单核细胞比值（LMR）在骨髓增生异常肿瘤患者中的预后作用。
The prognostic role of lymphocyte to monocyte ratio (LMR) in patients with Myelodysplastic Neoplasms.
机构信息
Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, People's Republic of China.
Key Laboratory of Hematology of Nanjing Medical University, Nanjing, People's Republic of China.
出版信息
Hematology. 2023 Dec;28(1):2210929. doi: 10.1080/16078454.2023.2210929.
BACKGROUND
Previous studies validated the prognostic significance of lymphocyte to monocyte ratio (LMR) in patients with solid tumors and some hematologic malignancies. However, the correlation between LMR and Myelodysplastic Neoplasms (MDS) was unclear. The study intends to investigate the prognostic impact of LMR on MDS patients.
METHODS
91 newly diagnosed MDS patients were included in this retrospective study. The cut-off of LMR was 3.2 by X-Tile. All patients were divided into the low LMR group (<3.2) and the high LMR group (≥3.2). Clinical characteristics were compared between the two groups.
RESULTS
Patients in the high LMR group (n = 67) had better OS ( = 0.007) from the Kaplan-Meier survival curves. The results of the univariate analysis demonstrated that LMR was a prognostic factor for OS [hazard ratio (HR) = 2.070, 95%CI 1.201-3.571, = 0.009]. After multivariate cox analysis, low LMR was confirmed to be an independent predictor of poor OS in MDS patients (HR = 1.872, 95%CI 1.084-3.230, = 0.024).
CONCLUSIONS
LMR, a representative marker of systematic inflammation and immune response, has potential prognostic significance in MDS patients.
背景
先前的研究已经验证了淋巴细胞与单核细胞比值（LMR）在实体瘤和一些血液恶性肿瘤患者中的预后意义。然而，LMR 与骨髓增生异常综合征（MDS）之间的相关性尚不清楚。本研究旨在探讨 LMR 对 MDS 患者的预后影响。
方法
本回顾性研究纳入了 91 例新诊断的 MDS 患者。通过 X-Tile 确定 LMR 的截断值为 3.2。所有患者均分为低 LMR 组（<3.2）和高 LMR 组（≥3.2）。比较两组患者的临床特征。
结果
Kaplan-Meier 生存曲线显示，高 LMR 组（n = 67）患者的总生存期（OS）更好（= 0.007）。单因素分析结果表明，LMR 是 OS 的预后因素[风险比（HR）= 2.070，95%CI 1.201-3.571，= 0.009]。多因素 Cox 分析后，低 LMR 被确认为 MDS 患者 OS 不良的独立预测因素（HR = 1.872，95%CI 1.084-3.230，= 0.024）。
结论
LMR 作为系统性炎症和免疫反应的代表性标志物，在 MDS 患者中具有潜在的预后意义。
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