Colloredo Mels G, Bettale G, Bellati G, Guanziroli M, Tiraboschi L, Angeli G, Idéo G
Acta Diabetol Lat. 1986 Jan-Mar;23(1):29-34. doi: 10.1007/BF02581351.
In the literature there is no agreement on the prevalence of chronic liver disease (CLD) and the role of hepatitis B virus (HBV) infection in diabetics. We undertook an epidemiological case-control study of the prevalence of CLD and HBV infection in 394 diabetics and 265 healthy subjects from Seriate and Como. The results did not show any significant differences between: 1) the prevalence of CLD in the diabetic population and in controls (4.8% vs 4.5%); 2) the prevalence of HBV infection in diabetics (HBsAg+: 8.3%; HBVAb+: 55.8%) and in controls (HBsAg+: 8.6%; HBVAb+: 54.7%); 3) the prevalence of HBV infection in diabetics with CLD (HBsAg+: 21%; HBVAb+: 52.6%) and in controls with CLD (HBsAg+: 16.6%; HBVAb+: 50%); 4) the prevalence of HBV infection in diabetics with and without CLD (HBsAg+: 21% vs 7.7%; HBVAb+: 52.6% vs 56%); 5) the prevalence of HBV infection in diabetics treated by injection and orally (HBsAg+: 6.9% vs 8.6%; HBVAb+: 58.3% vs 55.2%). The relative risk of CLD for the factor HBsAg+ was 3.2 in the diabetic population vs 1.4 in controls. In view of the presence of antidelta antibodies (HDVAb) in 25% of HBsAg+ diabetics with CLD and the lack of HBV markers in 26.3% of diabetics with CLD, we assume that other viruses (Delta, nonA-nonB) may play roles. Probably the interaction of all possible etiopathogenetic factors (alcohol, viruses, glycometabolic derangement) is determinant for CLD in diabetics.
关于慢性肝病（CLD）的患病率以及乙型肝炎病毒（HBV）感染在糖尿病患者中的作用，文献中尚无定论。我们对来自塞里亚泰和科莫的394例糖尿病患者和265名健康受试者进行了一项关于CLD患病率和HBV感染情况的流行病学病例对照研究。结果显示，以下各项之间均无显著差异：1）糖尿病患者人群与对照组中CLD的患病率（4.8%对4.5%）；2）糖尿病患者中HBV感染的患病率（HBsAg阳性：8.3%；HBVAb阳性：55.8%）与对照组中HBV感染的患病率（HBsAg阳性：8.6%；HBVAb阳性：54.7%）；3）患有CLD的糖尿病患者中HBV感染的患病率（HBsAg阳性：21%；HBVAb阳性：52.6%）与患有CLD的对照组中HBV感染的患病率（HBsAg阳性：16.6%；HBVAb阳性：50%）；4）患有CLD和未患有CLD的糖尿病患者中HBV感染的患病率（HBsAg阳性：21%对7.7%；HBVAb阳性：52.6%对56%）；5）接受注射治疗和口服治疗的糖尿病患者中HBV感染的患病率（HBsAg阳性：6.9%对8.6%；HBVAb阳性：58.3%对55.2%）。糖尿病患者人群中HBsAg阳性这一因素导致CLD的相对风险为3.2，而对照组中为1.4。鉴于25%的患有CLD的HBsAg阳性糖尿病患者中存在抗丁型肝炎病毒抗体（HDVAb），且26.3%的患有CLD的糖尿病患者中缺乏HBV标志物，我们推测其他病毒（丁型肝炎病毒、非甲非乙型肝炎病毒）可能起作用。可能所有可能的病因发病因素（酒精、病毒、糖代谢紊乱）之间的相互作用是糖尿病患者发生CLD的决定因素。
