Orholm M, Aldershvile J, Tage-Jensen U, Schlichting P, Nielsen J O, Hardt F, Christoffersen P
J Clin Pathol. 1981 Dec;34(12):1378-80. doi: 10.1136/jcp.34.12.1378.
The aim of this investigation was to elucidate a possible role of hepatitis B virus (HBV) in the pathogenesis of liver diseases in alcoholics. Two hundred and fifty-three alcoholics with liver disease were admitted to two medical departments in Copenhagen during a 15 months period. Seventy-nine patients (31%) showed serological signs (HBsAg, anti-HBs) of previous or active HBV infection. This is a significantly higher prevalence than found in an age-matched control population. Among the 79 patients with HBV markers, a total of 11 was found to be HBsAg-positive. From these 11 patients liver specimens were available for re-evaluation in nine cases. In only three of these liver biopsies, morphological changes indicating alcohol as the aetiological cause were found. In conclusion, different or concomitant aetiology must be considered in alcoholics with liver disease.
本研究的目的是阐明乙型肝炎病毒（HBV）在酒精性肝病发病机制中可能的作用。在15个月期间，253例患有肝病的酗酒者被收治到哥本哈根的两个内科。79例患者（31%）表现出既往或现症HBV感染的血清学迹象（HBsAg、抗-HBs）。这一患病率显著高于年龄匹配的对照人群。在79例有HBV标志物的患者中，共有11例HBsAg阳性。从这11例患者中，有9例可获得肝脏标本进行重新评估。在这些肝活检中，仅3例发现有提示酒精为病因的形态学改变。总之，对于患有肝病的酗酒者，必须考虑不同或并存的病因。
