Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214000, China; Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.
Biomed Pharmacother. 2023 Jul;163:114864. doi: 10.1016/j.biopha.2023.114864. Epub 2023 May 9.
Non-alcoholic fatty liver disease (NAFLD) is gradually becoming one of the most common and health-endangering diseases. Flaxseed powder (FLA) is rich in α-linolenic acid, dietary fiber, lignans, and other active ingredients, which have lipid-lowering and anti-inflammatory effects. Here, we investigated whether the FLA improves host metabolism by gut bacteria modulation and further bile acid modulation in mice fed a high-fat diet. At the end of the experiment, we found that FLA can significantly reduce the body weight, body fat content, and serum TG, LDL-C, and TNF-α levels of mice, and improve liver steatosis. FLA intervention has a significant effect on preventing and regulating the gut flora disturbance caused by HFD. FLA intervention affects bile acid metabolism in the intestine and causes significant changes in functional bile acids, which can play a lipid-lowering and anti-inflammatory role by activating the intestinal Fxr- Fgfr4-Cyp7a1 and Tgr5-Tlr4-Tnfα pathways.
非酒精性脂肪性肝病（NAFLD）逐渐成为最常见和危害健康的疾病之一。亚麻籽粉（FLA）富含α-亚麻酸、膳食纤维、木脂素等活性成分，具有降血脂和抗炎作用。在这里，我们研究了 FLA 是否通过调节肠道细菌和进一步调节胆汁酸来改善高脂肪饮食喂养的小鼠的宿主代谢。实验结束时，我们发现 FLA 可显著降低高脂饮食喂养小鼠的体重、体脂含量和血清 TG、LDL-C 和 TNF-α水平，并改善肝脂肪变性。FLA 干预对预防和调节 HFD 引起的肠道菌群失调有显著效果。FLA 干预影响肠道胆汁酸代谢，导致功能胆汁酸发生显著变化，通过激活肠道 Fxr-Fgfr4-Cyp7a1 和 Tgr5-Tlr4-Tnfα途径发挥降血脂和抗炎作用。
