Constanzo Felipe, Teixeira Bernardo Corrêa de Almeida, Sens Patricia, Smaili Hamzah, Escuissato Dante Luiz, Ramina Ricardo
Clínica Biobío, Concepción, Chile.
Hospital Clínico Regional de Concepción, Concepción, Chile.
Radiol Bras. 2023 Mar-Apr;56(2):67-74. doi: 10.1590/0100-3984.2022.0035.
The perfusion profile of vestibular schwannomas (VSs) and the factors that influence it have yet to be determined.
Twenty patients with sporadic VS were analyzed by calculating parameters related to the extravascular extracellular space (EES)-the volume transfer constant between a vessel and the EES (Ktrans); the EES volume per unit of tissue volume (Ve); and the rate transfer constant between EES and blood plasma (Kep)-as well as the relative cerebral blood volume (rCBV), and by correlating those parameters with the size of the tumor and its structure (solid, cystic, or heterogeneous).
Although Ktrans, Ve, and Kep were measurable in all tumors, rCBV was measurable only in large tumors. We detected a positive correlation between Ktrans and rCBV (r = 0.62, = 0.031), a negative correlation between Ve and Kep (r = -0.51, = 0.021), and a positive correlation between Ktrans and Ve only in solid VSs (r = 0.64, = 0.048). Comparing the means for small and large VSs, we found that the former showed lower Ktrans (0.13 vs. 0.029, < 0.001), higher Kep (0.68 vs. 0.46, = 0.037), and lower Ve (0.45 vs. 0.83, < 0.001). The mean Ktrans was lower in the cystic portions of cystic VSs than in their solid portions (0.14 vs. 0.32, < 0.001), as was the mean Ve (0.37 vs. 0.78, < 0.001). There were positive correlations between the solid and cystic portions for Ktrans (r = 0.71, = 0.048) and Kep (r = 0.74, = 0.037).
In VS, tumor size appears to be consistently associated with perfusion values. In cystic VS, the cystic portions seem to have lower Ktrans and Ve than do the solid portions.
前庭神经鞘瘤（VS）的灌注特征及其影响因素尚未确定。
通过计算与血管外细胞外间隙（EES）相关的参数——血管与EES之间的体积转移常数（Ktrans）；每单位组织体积的EES体积（Ve）；以及EES与血浆之间的速率转移常数（Kep）——以及相对脑血容量（rCBV），对20例散发性VS患者进行分析，并将这些参数与肿瘤大小及其结构（实性、囊性或异质性）进行关联。
虽然所有肿瘤均可测量Ktrans、Ve和Kep，但rCBV仅在大肿瘤中可测量。我们检测到Ktrans与rCBV之间呈正相关（r = 0.62，P = 0.031），Ve与Kep之间呈负相关（r = -0.51，P = 0.021），且仅在实性VS中Ktrans与Ve呈正相关（r = 0.64，P = 0.048）。比较小VS和大VS的均值，我们发现前者的Ktrans较低（0.13对0.029，P < 0.001），Kep较高（0.68对0.46，P = 0.037），Ve较低（0.45对0.83，P < 0.001）。囊性VS囊性部分的平均Ktrans低于实性部分（0.14对0.32，P < 0.001），平均Ve也是如此（0.37对0.78，P < 0.001）。Ktrans（r = 0.71，P = 0.048）和Kep（r = 0.74，P = 0.037）在实性和囊性部分之间呈正相关。
在VS中，肿瘤大小似乎始终与灌注值相关。在囊性VS中，囊性部分的Ktrans和Ve似乎低于实性部分。
