Multidisciplinary Head and Neck Cancer Center, National Institute of Oncology (NIO), Budapest, Hungary.
Center of Tumor Pathology Department, National Institute of Oncology (NIO), Budapest, Hungary.
Pathol Oncol Res. 2023 Apr 24;29:1611123. doi: 10.3389/pore.2023.1611123. eCollection 2023.
We aimed to characterize clinical and prognostical factors of primary head and neck squamous cell carcinoma (HNSCC) in 85 young patients (≤39 years, median age: 37 years; between 2000-2018) in comparison with 140 institutional general HNSCC patients (median age: 61.5 years). The patient's medical records were collected from the institutional database. The prevalence of smoking and alcohol consumption (65.8% and 48.1%) in the young group exceeded the regional population average but was below the institutional (86.4% and 55%) general HNSCC patient population. Primary tumor sites in the group of young patients were as follows: oral cavity (56.4%), oropharynx (17.6%), hypopharynx (11.7%), and larynx (14.1%). Cumulative five-year overall survival was 44.2% in the young group, but significantly better with early T (T1-2 vs. T3-4: 52.6% vs. 26.7%; = 0.0058) and N0 status (N0 vs. N+: 65.2% vs. 32.3%; = 0.0013). Young age, abstinence, earlier stage and laryngeal tumor site might predict a better prognosis. The age distribution and the high prevalence of traditional risk factors among the young patients as well as the predominance of oral cavity tumor localization suggest that the early onset of tumor development could be originated from the premature failure of the intrinsic protective mechanisms.
我们旨在描述 85 例≤39 岁（中位年龄：37 岁；2000-2018 年）原发性头颈部鳞状细胞癌（HNSCC）年轻患者的临床和预后因素，并与 140 例机构普通 HNSCC 患者（中位年龄：61.5 岁）进行比较。患者的病历是从机构数据库中收集的。年轻组的吸烟和饮酒率（65.8%和 48.1%）高于该地区的平均水平，但低于机构内（86.4%和 55%）普通 HNSCC 患者人群。年轻患者的原发肿瘤部位如下：口腔（56.4%）、口咽（17.6%）、下咽（11.7%）和喉（14.1%）。年轻组的五年总生存率为 44.2%，但 T 分期较早（T1-2 与 T3-4：52.6%与 26.7%； = 0.0058）和 N 分期较早（N0 与 N+：65.2%与 32.3%； = 0.0013）的患者预后明显更好。年轻、戒酒、早期分期和喉肿瘤部位可能预示着更好的预后。年轻患者的年龄分布和传统危险因素的高患病率，以及口腔肿瘤定位的优势，表明肿瘤的早期发展可能源于内在保护机制的过早失效。
