Villegas-Pineda Julio César, Ramírez-de-Arellano Adrián, Bueno-Urquiza Lesly Jazmín, Lizarazo-Taborda Mélida Del Rosario, Pereira-Suárez Ana Laura
Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
Front Oncol. 2023 Apr 24;13:1106757. doi: 10.3389/fonc.2023.1106757. eCollection 2023.
Molecular and cellular components of the tumor microenvironment are essential for cancer progression. The cellular element comprises cancer cells and heterogeneous populations of non-cancer cells that satisfy tumor needs. Immune, vascular, and mesenchymal cells provide the necessary factors to feed the tumor mass, promote its development, and favor the spread of cancer cells from the primary site to adjacent and distant anatomical sites. Cancer-associated fibroblasts (CAFs) are mesenchymal cells that promote carcinogenesis and progression of various malignant neoplasms. CAFs act through the secretion of metalloproteinases, growth factors, cytokines, mitochondrial DNA, and non-coding RNAs, among other molecules. Over the last few years, the evidence on the leading role of CAFs in gynecological cancers has notably increased, placing them as the cornerstone of neoplastic processes. In this review, the recently reported findings regarding the promoting role that CAFs play in gynecological cancers, their potential use as therapeutic targets, and the new evidence suggesting that they could act as tumor suppressors are analyzed and discussed.
肿瘤微环境的分子和细胞成分对癌症进展至关重要。细胞成分包括癌细胞和满足肿瘤需求的异质性非癌细胞群体。免疫细胞、血管细胞和间充质细胞提供必要的因子，以滋养肿瘤块、促进其发展，并有利于癌细胞从原发部位扩散到邻近和远处的解剖部位。癌症相关成纤维细胞（CAF）是促进各种恶性肿瘤发生和进展的间充质细胞。CAF通过分泌金属蛋白酶、生长因子、细胞因子、线粒体DNA和非编码RNA等分子发挥作用。在过去几年中，关于CAF在妇科癌症中主导作用的证据显著增加，使其成为肿瘤形成过程的基石。在这篇综述中，分析和讨论了最近报道的关于CAF在妇科癌症中促进作用的研究结果、它们作为治疗靶点的潜在用途，以及表明它们可能作为肿瘤抑制因子的新证据。
