Gharaibeh Besher A, Rababah Jehad, Haneyah Obieda
Jordan University of Science and Technology, Faculty of Nursing, Irbid, Jordan.
Int J Inflam. 2023 Apr 30;2023:7057458. doi: 10.1155/2023/7057458. eCollection 2023.
Patients with moderate or severe COVID-19 infection suffer from varying levels of fatigue; however, there is a lack of understanding regarding the effect of inflammation on fatigue; and whether these relationships differ according to the severity of the infection.
To assess the relationships between selected inflammatory biomarkers and fatigue levels among hospitalized Jordanian patients with moderate or severe COVID-19 infection.
A quantitative cross-sectional design was used. A total of 352 participants were recruited for the study. Data regarding fatigue type and level were collected using the Chalder fatigue scale. Laboratory test results regarding several selected inflammatory biomarkers (e.g., ESR, CRP, IL-6, D-dimer, and others) were collected from patient records. The severity of the COVID-19 infection was determined using the criteria of the Ministry of Health in Jordan based on the results of O% (oxygen saturation).
The mean scores of the total fatigue level significantly differed between the two levels of the severity of COVID-19 infection (moderate and severe levels) ( = -3.0, < 0.05). Similar findings were observed with physiological fatigue ( = -3.50, < 0.05), and no significant difference was observed in psychological fatigue. Out of the selected inflammatory markers, only neutrophil and lymphocyte count had a significant influence on total fatigue level.
The level and type of fatigue was affected by the severity of the disease. However, the disease process itself represented by the levels of the inflammatory markers showed little influence on fatigue. The implications such as continuous screening of fatigue, and monitoring of the levels of the inflammatory markers are important to assist in diagnosing and managing COVID-19 patients. Furthermore, the relationship between the inflammatory process and fatigue is complex and requires further exploration.
中度或重度新型冠状病毒肺炎（COVID-19）感染患者存在不同程度的疲劳；然而，对于炎症对疲劳的影响以及这些关系是否因感染严重程度而异，人们尚缺乏了解。
评估约旦住院的中度或重度COVID-19感染患者中选定的炎症生物标志物与疲劳水平之间的关系。
采用定量横断面设计。共招募了352名参与者进行研究。使用查尔德疲劳量表收集有关疲劳类型和程度的数据。从患者记录中收集有关几种选定炎症生物标志物（如红细胞沉降率、C反应蛋白、白细胞介素-6、D-二聚体等）的实验室检测结果。根据约旦卫生部基于血氧饱和度结果制定的标准确定COVID-19感染的严重程度。
COVID-19感染严重程度的两个级别（中度和重度）之间，总疲劳水平的平均得分存在显著差异（=-3.0，<0.05）。生理疲劳方面也观察到类似结果（=-3.50，<0.05），而心理疲劳方面未观察到显著差异。在选定的炎症标志物中，只有中性粒细胞和淋巴细胞计数对总疲劳水平有显著影响。
疲劳的程度和类型受疾病严重程度影响。然而，由炎症标志物水平所代表的疾病过程本身对疲劳的影响较小。持续筛查疲劳以及监测炎症标志物水平等措施对于协助诊断和管理COVID-19患者很重要。此外，炎症过程与疲劳之间的关系复杂，需要进一步探索。
