Rudroff Thorsten, Fietsam Alexandra C, Deters Justin R, Bryant Andrew D, Kamholz John
Department of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USA.
Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Brain Sci. 2020 Dec 19;10(12):1012. doi: 10.3390/brainsci10121012.
Much of the spotlight for coronavirus disease 2019 (COVID-19) is on the acute symptoms and recovery. However, many recovered patients face persistent physical, cognitive, and psychological symptoms well past the acute phase. Of these symptoms, fatigue is one of the most persistent and debilitating. In this "perspective article," we define fatigue as and propose a model to explain potential factors contributing to post-COVID-19 fatigue. According to our model, fatigue is dependent on conditional and physiological factors. Conditional dependency comprises the task, environment, and physical and mental capacity of individuals, while physiological factors include central, psychological, and peripheral aspects. This model provides a framework for clinicians and researchers. However, future research is needed to validate our proposed model and elucidate all mechanisms of fatigue due to COVID-19.
2019冠状病毒病（COVID-19）的大部分关注点都集中在急性症状和康复上。然而，许多康复患者在急性期过后仍面临持续的身体、认知和心理症状。在这些症状中，疲劳是最持久且使人衰弱的症状之一。在这篇“观点文章”中，我们对疲劳进行了定义，并提出了一个模型来解释导致COVID-19后疲劳的潜在因素。根据我们的模型，疲劳取决于条件因素和生理因素。条件依赖性包括任务、环境以及个体的身心能力，而生理因素包括中枢、心理和外周方面。该模型为临床医生和研究人员提供了一个框架。然而，需要未来的研究来验证我们提出的模型，并阐明COVID-19所致疲劳的所有机制。
