通过在基础和临床神经科学中调整复制概念来缩小转化研究差距。
Narrowing the translational research gap by aligning replication concepts in basic and clinical neuroscience.
机构信息
Departments of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Brain Institute and Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Brain Institute and Vanderbilt University, Nashville, TN 37232, USA.
出版信息
J Neurosci Methods. 2023 May 15;392:109878. doi: 10.1016/j.jneumeth.2023.109878. Epub 2023 May 9.
Replicability and reproducibility are widely considered to be cornerstones of valid scientific research. Yet, the elements of replication in fundamental neuroscience studies do not fully overlap with the process of replication in clinical neuroscience involving patients. Here we discuss how better aligning the concept of replication across this translational spectrum might enhance the rate at which basic findings in the organization and function of the nervous system are leveraged to develop new treatments for psychiatric and neurological disorders.
可重复性和可再现性被广泛认为是有效科学研究的基石。然而，基础神经科学研究中的复制要素与涉及患者的临床神经科学中的复制过程并不完全重叠。在这里，我们讨论了如何更好地在这个转化谱中统一复制的概念，以提高神经系统组织和功能的基础发现转化为精神和神经障碍新治疗方法的速度。
Zotero 插件