Ford Charles L, Young Larry J
Center for Translational Social Neuroscience, Silvio O. Conte Center for Oxytocin and Social Cognition, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Center for Translational Social Neuroscience, Silvio O. Conte Center for Oxytocin and Social Cognition, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: https://www.twitter.com/lyoun03.
Curr Opin Neurobiol. 2021 Jun;68:1-8. doi: 10.1016/j.conb.2020.11.007. Epub 2020 Nov 28.
The recent advancements of social behavioral neuroscience are unprecedented. Through manipulations targeting neural circuits, complex behaviors can be switched on and off, social bonds can be induced, and false memories can be 'incepted.' Psychiatry, however, remains tethered to concepts and techniques developed over half a century ago, including purely behavioral definitions of psychopathology and chronic, brain-wide pharmacological interventions. Drawing on recent animal and human research, we outline a circuit-level approach to the social brain and highlight studies demonstrating the translational potential of this approach. We conclude by suggesting ways both clinical practice and translational research can apply circuit-level neuroscientific knowledge to advance psychiatry, including adopting neuroscience-based nomenclature, stratifying patients into diagnostic subgroups based on neurobiological phenotypes, and pharmacologically enhancing psychotherapy.
社会行为神经科学的最新进展是前所未有的。通过针对神经回路的操纵，可以开启和关闭复杂行为、诱导社会联系以及“植入”错误记忆。然而，精神病学仍然依赖于半个多世纪前发展起来的概念和技术，包括精神病理学的纯行为定义以及慢性的、全脑范围的药物干预。借鉴最近的动物和人类研究，我们概述了一种针对社会大脑的回路水平方法，并强调了证明该方法具有转化潜力的研究。我们通过提出临床实践和转化研究如何应用回路水平的神经科学知识来推动精神病学发展的方法来得出结论，包括采用基于神经科学的命名法、根据神经生物学表型将患者分层为诊断亚组以及通过药物增强心理治疗。
