Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Xi'an 710038, China.
Department of Aerospace Medicine, The Fourth Military Medical University, Xi'an 710032, China.
Oxid Med Cell Longev. 2020 May 21;2020:6841581. doi: 10.1155/2020/6841581. eCollection 2020.
Persistent senescence seems to exert detrimental effects fostering ageing and age-related disorders, such as cancer. Chemotherapy is one of the most valuable treatments for cancer, but its clinical application is limited due to adverse side effects. Melatonin is a potent antioxidant and antiageing molecule, is nontoxic, and enhances the efficacy and reduces the side effects of chemotherapy. In this review, we first summarize the mitochondrial protective role of melatonin in the context of chemotherapeutic drug-induced toxicity. Thereafter, we tabulate the protective actions of melatonin against ageing and the harmful roles induced by chemotherapy and chemotherapeutic agents, including anthracyclines, alkylating agents, platinum, antimetabolites, mitotic inhibitors, and molecular-targeted agents. Finally, we discuss several novel directions for future research in this area. The information compiled in this review will provide a comprehensive reference for the protective activities of melatonin in the context of chemotherapy drug-induced toxicity and will contribute to the design of future studies and increase the potential of melatonin as a therapeutic agent.
持续衰老似乎会产生有害影响，促进癌症等衰老和与年龄相关的疾病。化疗是癌症最有价值的治疗方法之一，但由于其不良反应，其临床应用受到限制。褪黑素是一种有效的抗氧化剂和抗衰老分子，无毒性，并能提高化疗的疗效，降低其副作用。在这篇综述中，我们首先总结了褪黑素在化疗药物诱导的毒性中的线粒体保护作用。此后，我们列出了褪黑素对衰老的保护作用以及化疗和化疗药物引起的有害作用，包括蒽环类药物、烷化剂、铂类、抗代谢物、有丝分裂抑制剂和分子靶向药物。最后，我们讨论了该领域未来研究的几个新方向。本综述中汇编的信息将为褪黑素在化疗药物诱导的毒性中的保护作用提供全面的参考，并有助于未来研究的设计和提高褪黑素作为治疗剂的潜力。
