Mentzer R L, Budzynski A Z, Sherry S
Am J Cardiol. 1986 Jun 1;57(15):1220-6. doi: 10.1016/0002-9149(86)90192-x.
The effects in the circulating blood of a 1-hour intravenous infusion of 1.5 X 10(6) units of streptokinase (SK) were measured during the subsequent 24-hour period in 7 patients with acute myocardial infarction. At the end of the infusion, the activator activity, expressed in SK units, averaged 65 U/ml, all of the plasminogen had disappeared, only a small amount of free plasmin was still present and functionally active alpha 2 antiplasmin had been reduced to 21% of the preinfusion level. All of the native fibrinogen had been degraded and the thrombin-coagulable protein was composed entirely of fragment X species, but the circulating plasma also contained significant amounts of the more extensively degraded fragments Y, D and E. The biologic half-life of the SK-induced activator activity was 23 minutes and that of the fibrinogen degradation products was 6.3 hours. The lytic effects persisted for 4 hours before any signs of recovery from the hemostatic defect were evident; considerable recovery was present at 25 hours.
在7例急性心肌梗死患者中，于随后24小时期间测定了静脉输注1.5×10⁶单位链激酶（SK）1小时后循环血液中的效应。输注结束时，以SK单位表示的激活剂活性平均为65 U/ml，所有纤溶酶原均消失，仅存在少量游离纤溶酶且功能活跃，α2抗纤溶酶已降至输注前水平的21%。所有天然纤维蛋白原均已降解，凝血酶可凝固蛋白完全由X片段组成，但循环血浆中也含有大量降解程度更高的Y、D和E片段。SK诱导的激活剂活性的生物半衰期为23分钟，纤维蛋白原降解产物的生物半衰期为6.3小时。溶栓效应持续4小时，之后才出现止血缺陷恢复的任何迹象；25小时时已有相当程度的恢复。
