Labarrade Florian, Perrin Armelle, Ferreira Yolène, Botto Jean-Marie, Imbert Isabelle
Ashland Global Skin Research Centre, Sophia Antipolis, France.
Int J Cosmet Sci. 2023 Oct;45(5):604-611. doi: 10.1111/ics.12864. Epub 2023 May 28.
Throughout our existence, the skin senses and analyses the mechanical forces imposed by the environment. In response to these environmental forces, skin can deform itself and achieve a biological response. The subsequent cutaneous plasticity emerges from mechanical properties arising from the collective action of the skin cells, particularly keratinocytes, that govern the tensile strength via cell-to-cell adhesions and via cell-matrix adhesion structures. In addition to serving as force-bearing entities, keratinocytes respond to forces by activating signalling pathways to control their own fate and function. To detect and adapt to mechanical signals, keratinocytes possess a panel of sensory receptors and junctional intercellular structures. Mechanically activated ion channel Piezo1 has been described as a force sensor and as being involved in pleasant touch perception. In this study, relationships between Piezo1 modulation and oxytocin synthesis were investigated.
The expression of Piezo1 in the skin was studied and compared with the expression of TRPV1. Dooku1 antagonist and Jedi1 agonist were used to modulate Piezo1. The level of E-cadherin and oxytocin was monitored in ex vivo skin biopsies by immunodetection.
Taken together, our results illustrate the major role of mechanosensitive ion channel Piezo1 in skin barrier integrity, and in peripheral oxytocin synthesis in the skin.
In conclusion, this study highlights the relationships between pleasant touch, soft touch and local oxytocin synthesis.
在我们的整个生存过程中，皮肤感知并分析环境施加的机械力。作为对这些环境力的响应，皮肤能够自身变形并产生生物学反应。随后的皮肤可塑性源于皮肤细胞（特别是角质形成细胞）集体作用产生的机械特性，这些细胞通过细胞间粘附和细胞-基质粘附结构来控制抗张强度。除了作为受力实体外，角质形成细胞还通过激活信号通路来响应力，以控制自身的命运和功能。为了检测和适应机械信号，角质形成细胞拥有一系列感觉受体和连接性细胞间结构。机械激活离子通道Piezo1已被描述为一种力传感器，并参与愉悦触觉感知。在本研究中，研究了Piezo1调节与催产素合成之间的关系。
研究了皮肤中Piezo1的表达，并与TRPV1的表达进行比较。使用Dooku1拮抗剂和Jedi1激动剂来调节Piezo1。通过免疫检测监测离体皮肤活检组织中E-钙粘蛋白和催产素的水平。
综合来看，我们的结果说明了机械敏感离子通道Piezo1在皮肤屏障完整性以及皮肤外周催产素合成中的主要作用。
总之，本研究突出了愉悦触觉、轻柔触觉与局部催产素合成之间的关系。
