McCulloch E A, Minden M D, Buick R N, Izaguirre C A
Bull Cancer. 1978;65(4):443-8.
Diseaes originating in pluripotent stem cells, then developing through clonal expansion and clonal progression may properly be grouped together because of their common features. Among these, AML appears to be unique by reason of the presence within the clone of a blast cell population. Studies of cellular composition and regulation in AML clones require assays that measure not only myelopoiesis but also blast cell proliferation. The relation of the blast population to other components of AML clones remains uncertain. Resolution of the uncertainty is important in considering therapeutic strategies.
起源于多能干细胞，然后通过克隆扩增和克隆进展发展而来的疾病，因其共同特征可适当地归为一类。其中，急性髓系白血病（AML）似乎因其克隆内存在原始细胞群而独具特色。对AML克隆中的细胞组成和调控进行研究，需要的检测方法不仅要能测量髓系造血，还要能测量原始细胞增殖。原始细胞群与AML克隆其他成分的关系仍不明确。解决这一不确定性对于考虑治疗策略很重要。
