1Department of Radiology, Hainan Hospital of PLA General Hospital, Sanya 572013, China
The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China
Curr Med Imaging. 2024;20:e260423216207. doi: 10.2174/1573405620666230426125559.
Although iron deposition has been identified as a significant migraine trigger, the key structures in episodic migraine (EM) remain unknown.
The aim of this study is to investigate cerebral iron deposition in EM using an advanced voxel-based quantitative susceptibility mapping (QSM).
A multi-echo gradient echo sequence MR was performed in 15 episodic migraine patients (EMs) and 27 normal control subjects (NCs). The reconstructed quantitative susceptibility mapping images and voxel-based analysis were performed over the entire brain. The susceptibility value of all brain regions with altered iron deposition was extracted, and the correlations between susceptibility value and clinical variables (including HAMA, HAMD, MoCA, VAS, MIDAS score, diseased duration, and headache frequency) were calculated.
EM patients presented increased susceptibility value in the left putamen and bilateral substantia nigra (SN) compared with NC. There was no correlation between susceptibility value and the clinical variables.
Increased brain iron deposition in the extrapyramidal system may be a biomarker for migraine, and abnormal iron metabolism may be involved in the extrapyramidal mechanism. The QSM technique would be an optimal and simple tool for clinical practice and research in iron measurement.
尽管铁沉积已被确定为偏头痛的一个重要诱因，但阵发性偏头痛（EM）的关键结构仍不清楚。
本研究旨在使用先进的基于体素的定量磁化率映射（QSM）研究 EM 中的脑铁沉积。
对 15 例阵发性偏头痛患者（EMs）和 27 例正常对照者（NCs）进行多回波梯度回波序列 MR 检查。对全脑进行重建的定量磁化率映射图像和基于体素的分析。提取所有铁沉积改变的脑区的磁化率值，并计算磁化率值与临床变量（包括 HAMA、HAMD、MoCA、VAS、MIDAS 评分、疾病持续时间和头痛频率）之间的相关性。
与 NC 相比，EM 患者的左侧壳核和双侧黑质（SN）的磁化率值增加。磁化率值与临床变量之间无相关性。
锥体外系统脑铁沉积增加可能是偏头痛的生物标志物，异常铁代谢可能参与锥体外机制。QSM 技术将是一种用于铁测量的临床实践和研究的最佳和简单工具。
