Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China.
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Mol Pain. 2021 Jan-Dec;17:17448069211020894. doi: 10.1177/17448069211020894.
The previous documents demonstrated that iron deposition was identified in brain deep nuclei and periaqueductal gray matter region in chronic migraine (CM), and less is known about the cerebral iron deposition in CM. The aim of this study is to investigate the cerebral iron deposition in CM using an advanced voxel-based quantitative susceptibility mapping.
A multi-echo gradient echo MR sequence was obtained from 14 CM patients and 28 normal controls (NC), and quantitative susceptibility mapping images were reconstructed and voxel-based analysis was performed over the whole cerebrum. The susceptibility value of all the positive brain regions was extracted and correlation was calculated between the susceptibility value and the clinical variables.
The brain regions with increased susceptibility value in CM patients located in right precuneus, insula, supramarginal gyrus, dorsolateral superior frontal gyrus, postcentral gyrus, cuneus and left postcentral gyrus compared with NC. The correlation analysis demonstrated that a positive correlation was identified between susceptibility value of all the positive brain regions and VAS score.
The current study demonstrated increased cerebral iron deposition presented in chronic patients, which suggested that increased cerebral iron deposition might play a role in the migraine chronicization.
先前的文献表明，慢性偏头痛（CM）患者的脑深部核团和导水管周围灰质区域存在铁沉积，但关于 CM 患者脑内铁沉积的研究较少。本研究旨在采用先进的基于体素的定量磁化率映射来研究 CM 患者的脑内铁沉积。
对 14 例 CM 患者和 28 例正常对照者（NC）进行多回波梯度回波 MR 序列采集，并重建定量磁化率图，对全脑进行基于体素的分析。提取所有阳性脑区的磁化率值，并计算磁化率值与临床变量之间的相关性。
与 NC 相比，CM 患者脑内磁化率值升高的区域位于右侧顶下小叶、岛叶、缘上回、额上回背外侧部、中央后回、楔叶和左侧中央后回。相关性分析表明，所有阳性脑区的磁化率值与 VAS 评分呈正相关。
本研究表明，慢性偏头痛患者存在脑内铁沉积增加，提示脑内铁沉积增加可能在偏头痛慢性化过程中起作用。
