Mendenhall C L, Rouster S, Marshall L, Weesner R
Am J Gastroenterol. 1986 Jul;81(7):540-3.
This report describes a new therapeutic approach to the treatment of adults with portal systemic encephalopathy using sodium benzoate and sodium phenylacetate, two compounds that increase conjugated nitrogen excretion in the urine and that have been shown to be an effective treatment for children with congenital hyperammonemia. The study was a double-blind cross-over study in which each patient was his own control. All patients either improved their mental status (six of eight) or maintained a mental status comparable to that achieved with conventional therapy [lactulose or neomycin (two of eight)]. All decreased their blood ammonias on these medications and seven of eight improved their portal systemic encephalopathy index. It is suggested that these medications may be useful in the treatment of portal systemic encephalopathy.
本报告描述了一种治疗成人门体性脑病的新方法，即使用苯甲酸钠和苯乙酸钠，这两种化合物可增加尿中结合氮的排泄，且已被证明对先天性高氨血症儿童有效。该研究为双盲交叉研究，每位患者自身作为对照。所有患者要么改善了精神状态（8例中的6例），要么维持了与传统疗法（乳果糖或新霉素，8例中的2例）相当的精神状态。所有患者在使用这些药物后血氨水平均下降，8例中的7例改善了门体性脑病指数。提示这些药物可能对门体性脑病的治疗有用。
