Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Curr Probl Cardiol. 2023 Sep;48(9):101794. doi: 10.1016/j.cpcardiol.2023.101794. Epub 2023 May 11.
Out-of-hospital Cardiac Arrest (OHCA) is the abrupt cessation of cardiac function outside of a hospital setting. With limited research into the presence of racial disparities among outcomes of OHCA patients, this systematic review and meta-analysis was conducted. PubMed, Cochrane, and Scopus were searched from inception to March 2023. This analysis includes a total of 53,507 black patients, and 185,173 white patients, resulting in the pooling of 238,680 patients in this meta-analysis. It was observed that the black population was associated with significantly worsened survival to hospital discharge (OR: 0.81; 95% CI: 0.68, 0.96, P = 0.01), return of spontaneous circulation (OR: 0.79; 95% CI: 0.69, 0.89, P = 0.0002), and neurological outcomes (OR: 0.80; 95% CI: 0.68, 0.93; P = 0.003) when compared to their white counterparts. However, there were no differences found with respect to mortality. To the best of our knowledge, this is the most comprehensive meta-analysis assessing racial disparities in OHCA outcomes that have never been explored before. Increased awareness programs, and greater racial inclusivity in the field of cardiovascular medicine is encouraged. Further studies are needed in order to arrive at a robust conclusion.
院外心脏骤停（OHCA）是指在医院环境之外心脏功能突然停止。由于对 OHCA 患者结局中存在种族差异的研究有限，因此进行了这项系统评价和荟萃分析。从成立到 2023 年 3 月，我们在 PubMed、Cochrane 和 Scopus 上进行了搜索。这项分析共纳入了 53507 名黑人患者和 185173 名白人患者，共有 238680 名患者纳入荟萃分析。结果观察到，黑人患者与出院时生存率显著降低（OR：0.81；95%CI：0.68，0.96，P=0.01）、自主循环恢复（OR：0.79；95%CI：0.69，0.89，P=0.0002）和神经功能结局（OR：0.80；95%CI：0.68，0.93；P=0.003）较差有关，与白人患者相比。然而，在死亡率方面没有差异。据我们所知，这是评估 OHCA 结局中种族差异的最全面的荟萃分析，以前从未对此进行过探索。鼓励在心血管医学领域开展更多的提高认识计划，并增加种族包容性。需要进一步的研究以得出可靠的结论。
