Department of Microbiology, Ramón y Cajal Institute for Health Research (IRYCIS), Ramón y Cajal University Hospital, Madrid, Spain; CIBER in Infectious Diseases (CIBERINFEC), Madrid, Spain.
Department of Microbiology, Ramón y Cajal Institute for Health Research (IRYCIS), Ramón y Cajal University Hospital, Madrid, Spain; CIBER in Infectious Diseases (CIBERINFEC), Madrid, Spain.
Trends Microbiol. 2023 Sep;31(9):972-984. doi: 10.1016/j.tim.2023.04.006. Epub 2023 May 10.
A thriving multi-kingdom microbial ecosystem inhabits the respiratory tract: the respiratory tract microbiome (RTM). In recent years, the contribution of the RTM to human health has become a crucial research aspect. However, research into the key ecological processes, such as robustness, resilience, and microbial interaction networks, has only recently started. This review leans on an ecological framework to interpret the human RTM and determine how the ecosystem functions and assembles. Specifically, the review illustrates the ecological RTM models and discusses microbiome establishment, community structure, diversity stability, and critical microbial interactions. Lastly, the review outlines the RTM responses to ecological disturbances, as well as the promising approaches for restoring ecological balance.
呼吸道微生物组（RTM）。近年来，RTM 对人类健康的贡献已成为一个关键的研究方面。然而，对关键生态过程的研究，如鲁棒性、弹性和微生物相互作用网络，最近才刚刚开始。本综述基于生态框架来解释人类 RTM，并确定生态系统的功能和组装方式。具体来说，本综述说明了生态 RTM 模型，并讨论了微生物组的建立、群落结构、多样性稳定性和关键微生物相互作用。最后，本综述概述了 RTM 对生态干扰的反应，以及恢复生态平衡的有前途的方法。
