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CEP55：一种与免疫相关的多种癌症的预测和预后分子生物标志物。

CEP55: an immune-related predictive and prognostic molecular biomarker for multiple cancers.

机构信息

Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, No. 6, Shuangyong Road, 530021, Nanning, P. R. China.

Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, No. 6, Shuangyong Road, 530021, Nanning, P. R. China.

出版信息

BMC Pulm Med. 2023 May 12;23(1):166. doi: 10.1186/s12890-023-02452-1.

DOI:10.1186/s12890-023-02452-1
PMID:37173675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10182662/
Abstract

BACKGROUND: Centrosomal protein 55 (CEP55) plays a significant role in specific cancers. However, comprehensive research on CEP55 is lacking in pan-cancer. METHODS: In-house and multi-center samples (n = 15,823) were used to analyze CEP55 in 33 cancers. The variance of CEP55 expression levels among tumor and control groups was evaluated by the Wilcoxon rank-sum test and standardized mean difference (SMD). The clinical value of CEP55 in cancers was assessed using receiver operating characteristic (ROC) curves, Cox regression analysis, and Kaplan-Meier curves. The correlations between CEP55 expression and the immune microenvironment were explored using Spearman's correlation coefficient. RESULTS: The data of clustered regularly interspaced short palindromic repeats confirmed that CEP55 was essential for the survival of cancer cells in multiple cancer types. Elevated CEP55 mRNA expression was observed in 20 cancers, including glioblastoma multiforme (p < 0.05). CEP55 mRNA expression made it feasible to distinguish 21 cancer types between cancer specimens and their control samples (AUC = 0.97), indicating the potential of CEP55 for predicting cancer status. Overexpression of CEP55 was correlated with the prognosis of cancer individuals for 18 cancer types, exhibiting its prognostic value. CEP55 expression was relevant to tumor mutation burden, microsatellite instability, neoantigen counts, and the immune microenvironment in various cancers (p < 0.05). The expression level and clinical relevance of CEP55 in cancers were verified in lung squamous cell carcinoma using in-house and multi-center samples (SMD = 4.07; AUC > 0.95; p < 0.05). CONCLUSION: CEP55 may be an immune-related predictive and prognostic marker for multiple cancers, including lung squamous cell carcinoma.

摘要

背景：中心体蛋白 55（CEP55）在特定癌症中发挥着重要作用。然而，在泛癌症中，对 CEP55 的综合研究还很缺乏。

方法：使用内部和多中心样本（n=15823）分析 33 种癌症中的 CEP55。Wilcoxon 秩和检验和标准化均数差（SMD）评估肿瘤组和对照组之间 CEP55 表达水平的差异。使用接收者操作特征（ROC）曲线、Cox 回归分析和 Kaplan-Meier 曲线评估 CEP55 在癌症中的临床价值。使用 Spearman 相关系数探索 CEP55 表达与免疫微环境之间的相关性。

结果：聚类规则间隔短回文重复数据证实 CEP55 对多种癌症类型的癌细胞存活至关重要。20 种癌症中观察到 CEP55 mRNA 表达升高，包括多形性胶质母细胞瘤（p<0.05）。CEP55 mRNA 表达可区分癌症标本和对照样本中的 21 种癌症类型（AUC=0.97），表明 CEP55 具有预测癌症状态的潜力。CEP55 的过表达与 18 种癌症类型中癌症个体的预后相关，表现出其预后价值。CEP55 表达与各种癌症中的肿瘤突变负担、微卫星不稳定性、新抗原计数和免疫微环境相关（p<0.05）。使用内部和多中心样本验证了 CEP55 在肺鳞状细胞癌中的表达水平和临床相关性（SMD=4.07；AUC>0.95；p<0.05）。

结论：CEP55 可能是多种癌症的一种与免疫相关的预测和预后标志物，包括肺鳞状细胞癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/590aab159009/12890_2023_2452_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/833a258b926d/12890_2023_2452_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/690d7dbc180a/12890_2023_2452_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/4e1e8106913e/12890_2023_2452_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/c89d97cebed3/12890_2023_2452_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/d25547df0c32/12890_2023_2452_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/8bb4b55c4016/12890_2023_2452_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/2960ed23f1a7/12890_2023_2452_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/13fb31e1c48f/12890_2023_2452_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/590aab159009/12890_2023_2452_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/833a258b926d/12890_2023_2452_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/690d7dbc180a/12890_2023_2452_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/4e1e8106913e/12890_2023_2452_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/c89d97cebed3/12890_2023_2452_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/d25547df0c32/12890_2023_2452_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/8bb4b55c4016/12890_2023_2452_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/2960ed23f1a7/12890_2023_2452_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/13fb31e1c48f/12890_2023_2452_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ec/10182662/590aab159009/12890_2023_2452_Fig9_HTML.jpg

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