Tondolo Vincenzo, Casà Calogero, Rizzo Gianluca, Leone Mariavittoria, Quero Giuseppe, Alfieri Virginia, Boldrini Luca, Bulajic Milutin, Corsi Domenico, Micciché Francesco
U.O.C. di Chirurgia Digestiva e del Colon-Retto, Fatebenefratelli Isola Tiberina, Gemelli Isola, 00186 Rome, Italy.
U.O.C. di Radioterapia Oncologica, Fatebenefratelli Isola Tiberina, Gemelli Isola, 00186 Rome, Italy.
Cancers (Basel). 2023 May 3;15(9):2597. doi: 10.3390/cancers15092597.
Esophagogastric junction (EGJ) carcinoma represents a specific site of disease, given the opportunities for multimodal clinical care and management and the possibilities of combined treatments. It encompasses various clinical subgroups of disease that are heterogeneous and deserve different treatments; therefore, the guidelines have progressively evolved over time, considering the evidence provided by clinical trials. The aim of this narrative review was to summarize the main evidence, which orientates the current guidelines, and to collect the main ongoing studies to address existing gray areas.
鉴于存在多模式临床护理和管理的机会以及联合治疗的可能性，食管胃交界（EGJ）癌是一种特殊的疾病部位。它包括各种不同的临床疾病亚组，需要不同的治疗方法；因此，考虑到临床试验提供的证据，相关指南也在不断发展。本叙述性综述的目的是总结指导当前指南的主要证据，并收集正在进行的主要研究以解决现有模糊领域的问题。
