Bastos Ana Raquel, Pereira-Marques Joana, Ferreira Rui Manuel, Figueiredo Ceu
Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), 4200-135 Porto, Portugal.
Department of Pathology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Cancers (Basel). 2023 May 5;15(9):2629. doi: 10.3390/cancers15092629.
Pancreatic cancer mortality is expected to rise in the next decades. This aggressive malignancy has a dismal prognosis due to late diagnosis and resistance to treatment. Increasing evidence indicates that host-microbiome interactions play an integral role in pancreatic cancer development, suggesting that harnessing the microbiome might offer promising opportunities for diagnostic and therapeutic interventions. Herein, we review the associations between pancreatic cancer and the intratumoral, gut and oral microbiomes. We also explore the mechanisms with which microbes influence cancer development and the response to treatment. We further discuss the potentials and limitations of using the microbiome as a target for therapeutic interventions, in order to improve pancreatic cancer patient outcomes.
预计在未来几十年中，胰腺癌死亡率将会上升。这种侵袭性恶性肿瘤由于诊断较晚且对治疗耐药，预后很差。越来越多的证据表明，宿主与微生物组的相互作用在胰腺癌发展过程中起着不可或缺的作用，这表明利用微生物组可能为诊断和治疗干预提供有前景的机会。在此，我们综述了胰腺癌与肿瘤内、肠道及口腔微生物组之间的关联。我们还探讨了微生物影响癌症发展及治疗反应的机制。我们进一步讨论了将微生物组作为治疗干预靶点的潜力和局限性，以期改善胰腺癌患者的预后。
