König Marie-Thérèse, Frölich Kai, Jandowsky Anabell, Knauf-Witzens Tobias, Langner Christoph, Dietrich Richard, Märtlbauer Erwin, Didier Andrea
Department of Veterinary Sciences, Institute of Food Science, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Schönleutnerstraße 8, 85764 Oberschleißheim, Germany.
Tierpark Arche Warder, Zentrum für Seltene Nutztierrassen e. V., Langwedeler Weg 11, 24646 Warder, Germany.
Animals (Basel). 2023 Apr 27;13(9):1492. doi: 10.3390/ani13091492.
Circular replicase-encoding single-stranded (CRESS) DNA viruses and other circular DNA agents are increasingly found in various samples and animals. A specific class of these agents-termed bovine meat and milk factors (BMMF)-has been supposed to act as a factor in indirect carcinogenesis in humans. Initial observations attributed the BMMF to European cattle breeds and foodstuffs produced thereof. In the present study, blood and fecal samples from African and Asian cattle were examined. BMMF molecules and genomoviruses were detected in all bovids under study. The majority (79%) of the 29 circular elements could be assigned to BMMF groups 1 and 2, whereas CRESS viruses of the family accounted for the smaller part (21%). Two genomoviruses belong to the genus and one to the genus . The remaining three might be considered as novel species within the genus . The majority of all isolated molecules originated from fecal samples, whereas only three derived from blood. The results from this study expand our knowledge on the diversity and presence of circular DNA in different ruminants that serve for food production in many countries over the world.
环状复制酶编码单链（CRESS）DNA病毒和其他环状DNA因子在各种样本和动物中越来越多地被发现。这类因子中的一个特定类别——称为牛肉和牛奶因子（BMMF）——被认为是人类间接致癌的一个因素。最初的观察将BMMF归因于欧洲牛品种及其生产的食品。在本研究中，对来自非洲和亚洲牛的血液和粪便样本进行了检测。在所研究的所有牛科动物中均检测到了BMMF分子和基因组病毒。29个环状元件中的大多数（79%）可归为BMMF第1组和第2组，而该科的CRESS病毒占较小部分（21%）。两种基因组病毒属于 属，一种属于 属。其余三种可能被视为该属内的新物种。所有分离出的分子大多来自粪便样本，而只有三个来自血液。这项研究的结果扩展了我们对世界上许多国家用于食品生产的不同反刍动物中环状DNA的多样性和存在情况的认识。
