Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 743-8551, Japan.
Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima 734-8553, Japan.
Cells. 2023 May 1;12(9):1293. doi: 10.3390/cells12091293.
Dyslipidemia is associated with endothelial dysfunction. Endothelial dysfunction is the initial step for atherosclerosis, resulting in cardiovascular complications. It is clinically important to break the process of endothelial dysfunction to cardiovascular complications in patients with dyslipidemia. Lipid-lowering therapy enables the improvement of endothelial function in patients with dyslipidemia. It is likely that the relationships of components of a lipid profile such as low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides with endothelial function are not simple. In this review, we focus on the roles of components of a lipid profile in endothelial function.
血脂异常与血管内皮功能障碍有关。血管内皮功能障碍是动脉粥样硬化的初始步骤，导致心血管并发症。对于血脂异常患者，打破血管内皮功能障碍向心血管并发症的进程具有重要的临床意义。降脂治疗可改善血脂异常患者的血管内皮功能。血脂谱成分（如低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯）与血管内皮功能的关系可能并不简单。在这篇综述中，我们重点关注血脂谱成分在血管内皮功能中的作用。
