Al Kitani Mahfoodha
Physical Education & Sport Sciences Department, College of Education, Sultan Qaboos University, Muscat, Oman.
Front Sports Act Living. 2025 May 7;7:1560669. doi: 10.3389/fspor.2025.1560669. eCollection 2025.
Elevated plasma triacylglycerol (TAG) levels are associated with endothelial dysfunction, inflammation, and increased vascular complications, particularly in populations such as individuals with sickle cell disease (SCD). This study aimed to investigate the effect of a single exercise session on postprandial TAG levels in children with SCD following the consumption of a high-fat meal. The high-fat meal was used to induce a significant postprandial increase in plasma triayglecrol (TAG) levels, aknown risk factor for endothelial dysfunction and vascular implication, particualry in population with Sickle Cell Disease (SCD). Twelve male children with SCD (mean age: 10.5 ± 1.2 years) participated in two 2-day trials, one involving brisk walking (exercise trial) and one with rest (rest trial), in a randomized, counter-balanced design. A mixed high-fat test meal (97 g fat, 124 g carbohydrate, 1,450 kcal) was administered after a 10-h overnight fast, and blood samples were collected at baseline, 60, 120, 240, 300, and 360 min post-meal to measure serum TAG, glucose, insulin, and total cholesterol concentrations. Postprandial TAG levels significantly increased in both trials, but the exercise trial showed a significantly lower TAG response compared to the rest trial ( < 0.05). The area under the curve (AUC) for TAG was greater in the rest trial than in the exercise trial ( < 0.05). Specifically, TAG concentrations were significantly lower in the exercise trial at 120 and 180 min post-meal ( < 0.05), indicating faster clearance of TAG following exercise. Insulin and glucose concentrations also increased post-meal, with significantly lower insulin and glucose AUC values in the exercise trial compared to the rest trial ( < 0.05). No significant differences were observed in total cholesterol between the two trials at 360 min post-meal. These findings suggest that a single bout of exercise prior to a high-fat meal reduces postprandial TAG concentrations in children with SCD, consistent with previous studies in healthy populations. The reduction in postprandial TAG may have implications for improving endothelial function and reducing the risk of cardiovascular and vaso-occlusive events in individuals with SCD. Further studies are needed to explore the long-term effects of regular exercise on lipid metabolism and disease complications in this population.
血浆甘油三酯（TAG）水平升高与内皮功能障碍、炎症及血管并发症增加有关，尤其是在镰状细胞病（SCD）患者等人群中。本研究旨在调查单次运动对SCD患儿高脂餐后餐后TAG水平的影响。高脂餐用于诱导餐后血浆甘油三酯（TAG）水平显著升高，这是内皮功能障碍和血管病变的一个已知危险因素，尤其在镰状细胞病（SCD）人群中。12名患有SCD的男性儿童（平均年龄：10.5±1.2岁）参与了两项为期2天的试验，一项是快走（运动试验），另一项是休息（休息试验），采用随机、交叉平衡设计。在禁食10小时后给予混合高脂试验餐（97克脂肪、124克碳水化合物、1450千卡），并在餐后基线、60、120、240、300和360分钟采集血样，以测量血清TAG、葡萄糖、胰岛素和总胆固醇浓度。两项试验中餐后TAG水平均显著升高，但运动试验的TAG反应明显低于休息试验（P<0.05）。休息试验中TAG的曲线下面积（AUC）大于运动试验（P<0.05）。具体而言，运动试验中餐后120和180分钟时TAG浓度显著较低（P<0.05），表明运动后TAG清除更快。胰岛素和葡萄糖浓度餐后也升高，运动试验中的胰岛素和葡萄糖AUC值显著低于休息试验（P<0.05）。餐后360分钟时，两项试验的总胆固醇无显著差异。这些发现表明，高脂餐前单次运动可降低SCD患儿的餐后TAG浓度，这与之前在健康人群中的研究一致。餐后TAG的降低可能对改善SCD患者的内皮功能及降低心血管和血管闭塞事件的风险有意义。需要进一步研究来探索规律运动对该人群脂质代谢和疾病并发症的长期影响。
