Samakidou Georgia E, Koliaki Chrysi C, Liberopoulos Evangelos N, Katsilambros Nikolaos L
Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece.
Healthcare (Basel). 2023 May 3;11(9):1310. doi: 10.3390/healthcare11091310.
Obesity is a chronic disease and a major public health problem due to its association with non-communicable diseases and all-cause mortality. An increased energy intake and decreased physical activity have been long recognized as the classical parameters that contribute to the development of obesity. However, several other, non-classical factors have also been associated with obesity through various complex mechanisms. Some of them are diet related, such as diet quality, dietary habits and speed of eating. Other factors are non-dietary, such as endocrine-disrupting chemicals, sleep quality and quantity, psychotropic medications and light at night. The scope of the present narrative review is to address these non-classical factors that are implicated in the pathogenesis of obesity, to clarify their potential role in the management of obesity and, where possible, to provide some practical clinical recommendations.
肥胖是一种慢性疾病，也是一个重大的公共卫生问题，因为它与非传染性疾病及全因死亡率相关。长期以来，能量摄入增加和身体活动减少一直被认为是导致肥胖发生的经典因素。然而，其他一些非经典因素也通过各种复杂机制与肥胖相关。其中一些与饮食有关，如饮食质量、饮食习惯和进食速度。其他因素则与饮食无关，如内分泌干扰化学物质、睡眠质量和时长、精神药物以及夜间光照。本叙述性综述的范围是探讨这些与肥胖发病机制相关的非经典因素，阐明它们在肥胖管理中的潜在作用，并在可能的情况下提供一些实用的临床建议。
