Center for Pharmaceutical Sciences, Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus, Kunming 650500, China.
State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Molecules. 2023 May 6;28(9):3927. doi: 10.3390/molecules28093927.
H. Lév. and Vaniot is a variety of Chinese mugwort widely cultured in central China. Lamotte, another variety of Chinese mugwort, has been used in the southern region of China since ancient times. Despite their similar uses in traditional medicine, little is known about the differences in their active ingredients and potential benefits. Herein, the chemical compositions of the essential oils (EOs) from both varieties were analyzed using chromatography-mass spectrometry (GC-MS). A series of databases, such as the Traditional Chinese Medicine Systems Pharmacology database (TCMSP), SuperPred database and R tool, were applied to build a networking of the EOs. Our results revealed significant differences in the chemical compositions of the two EOs. However, we found that they shared similar ingredient-target-pathway networking with diverse bioactivities, such as neuroprotective, anti-cancer and anti-inflammatory. Furthermore, our protein connection networking analysis showed that transcription factor p65 (RELA), phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) and mitogen-activated protein kinase 1 (MAPK1) are crucial for the biological activity of EOs. Our findings provided evidence for the use of as Chinese mugwort in southern China.
Lév. 和 Vaniot 是一种广泛种植于中国中部的艾蒿变种。另一种艾蒿变种 Lamotte 自古以来就在中国南方使用。尽管它们在传统医学中有相似的用途，但对于它们的活性成分和潜在益处的差异知之甚少。在这里，使用色谱-质谱联用仪 (GC-MS) 分析了这两种精油 (EO) 的化学成分。一系列数据库，如中药系统药理学数据库 (TCMSP)、SuperPred 数据库和 R 工具，被应用于构建 EO 的网络。我们的结果显示，两种 EO 的化学成分存在显著差异。然而，我们发现它们具有相似的成分-靶标-途径网络，具有多种生物活性，如神经保护、抗癌和抗炎。此外，我们的蛋白质连接网络分析表明，转录因子 p65 (RELA)、磷脂酰肌醇 3-激酶调节亚基α (PIK3R1) 和丝裂原活化蛋白激酶 1 (MAPK1) 对于 EO 的生物活性至关重要。我们的发现为中国南方使用 作为艾蒿变种提供了证据。
