Deng Pengfei, Wang Huiling, Xu Xiaoniu
School of Forestry & Landscape Architecture, Anhui Agricultural University, Hefei 230036, China.
Anhui Provincial Key Laboratory of Forest Resources and Silviculture, Anhui Agricultural University, Hefei 230036, China.
Plants (Basel). 2024 Sep 21;13(18):2640. doi: 10.3390/plants13182640.
(, Taxaceae) is a well-known nut tree species. Its fruit aril and leaves possess a unique aroma, making it an ideal natural raw material for extracting essential oils (EOs). This study aims to comprehensively compare the composition, biological activities, and pharmacological mechanism of EOs extracted from the arils (AEO) and leaves (LEO) of . The results revealed that the chemical composition of the two EOs was highly consistent, with -pinene and D-limonene as the main components. Both EOs significantly reduced cellular melanin production and inhibited tyrosinase activity in -MSH-stimulated B16 cells ( < 0.05). AEO and LEO suppressed inflammatory responses in LPS-stimulated RAW 264.7 macrophages, significantly inhibiting cellular NO production and proinflammatory cytokines such as TNF- and IL-6 ( < 0.05). A network pharmacology analysis reveals that AEO and LEO share similar molecular mechanisms and pharmacological pathways for treating skin pigmentation and inflammation. Regulating inflammatory cytokines may be a critical pathway for AEO and LEO in treating skin pigmentation. These findings suggest that AEO and LEO have potential for cosmetic applications. The leaves of could be a valuable source of supplementary materials for producing aril EO.
（红豆杉科）是一种著名的坚果类树种。其果实假种皮和叶子具有独特的香气，使其成为提取精油（EOs）的理想天然原料。本研究旨在全面比较从[树种名称]的假种皮（AEO）和叶子（LEO）中提取的精油的成分、生物活性和药理机制。结果表明，两种精油的化学成分高度一致，以α-蒎烯和D-柠檬烯为主要成分。两种精油均显著降低细胞黑色素生成，并抑制α-MSH刺激的B16细胞中的酪氨酸酶活性（P<0.05）。AEO和LEO抑制LPS刺激的RAW 264.7巨噬细胞中的炎症反应，显著抑制细胞NO生成以及促炎细胞因子如TNF-α和IL-6（P<0.05）。网络药理学分析表明，AEO和LEO在治疗皮肤色素沉着和炎症方面具有相似的分子机制和药理途径。调节炎症细胞因子可能是AEO和LEO治疗皮肤色素沉着的关键途径。这些发现表明，AEO和LEO具有化妆品应用潜力。[树种名称]的叶子可能是生产[树种名称]假种皮精油的宝贵补充材料来源。
