香料精油抑制胆碱酯酶活性并改善 AlCl 诱导的痴呆行为障碍。
Essential Oils from Spices Inhibit Cholinesterase Activity and Improve Behavioral Disorder in AlCl Induced Dementia.
机构信息
Center for Pharmaceutical Sciences, Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus, Kunming, 650500, P. R. China.
Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, P. R. China.
出版信息
Chem Biodivers. 2022 Jan;19(1):e202100443. doi: 10.1002/cbdv.202100443. Epub 2021 Dec 6.
The chemical compositions of essential oils (EOs) prepared from six spices including cinnamon, amomum tsao-ko, cardamom, amomum, black pepper and white pepper were analyzed by gas chromatography-mass spectrometry (GC/MS), which led to identify almost 200 volatile compounds. All EOs of spices showed cholinesterase inhibitory activity. Among them, pepper EO showed most potent acetylcholinesterase (AChE) inhibitory activity with IC values of 8.54 μg/mL (black pepper EO) and 5.02 μg/mL (white pepper EO). Molecular docking and in vitro validation suggested that 3-carene, α-pinene and β-pinene with IC value of 1.73, 2.66, and 14.75 μg/mL, respectively, might be active constituents of spices oil in inhibiting AChE. Furthermore, amomum tsao-ko EO and amomum EO can improve behavioral disorder in dementia zebrafish induced by aluminum trichloride (AlCl ).
六种香料（肉桂、草果、小豆蔻、荜茇、黑胡椒和白胡椒）制成的精油（EOs）的化学成分通过气相色谱-质谱联用技术（GC/MS）进行了分析，鉴定出近 200 种挥发性化合物。所有香料的 EOs 均表现出胆碱酯酶抑制活性。其中，胡椒 EO 对乙酰胆碱酯酶（AChE）的抑制活性最强，IC 值分别为 8.54μg/mL（黑胡椒 EO）和 5.02μg/mL（白胡椒 EO）。分子对接和体外验证表明，3-蒈烯、α-蒎烯和β-蒎烯的 IC 值分别为 1.73μg/mL、2.66μg/mL 和 14.75μg/mL，可能是香料油抑制 AChE 的活性成分。此外，草果和荜茇精油可改善三氯化铝（AlCl ）诱导的痴呆斑马鱼的行为障碍。
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