Levy W J
Anesthesiology. 1986 Jun;64(6):688-93. doi: 10.1097/00000542-198606000-00003.
In order to correlate electroencephalogram (EEG) changes during anesthetic induction with level of consciousness, four-channel parasagittal EEG recordings were made during anesthetic induction with enflurane and enflurane-nitrous oxide in oxygen. The EEG was quantitated using power spectrum analysis. Significant EEG changes were identified during all anesthetic inductions; however, the frequency of occurrence of change was significant only during development of amnesia (15 of 20 subjects, P = 0.04). The nature of the EEG changes at this time was agent-specific (P less than 0.05 by chi-square), with high-frequency changes evident in the enflurane group and shifts in amplitude in the 8-12 Hz activity predominating in the nitrous oxide-enflurane group. Anterior dominance could not be documented as a correlate of amnesia or unresponsiveness. The identification of such EEG changes may be valuable in assessing anesthetic depth, but other effects, such as the response of the EEG to surgical stimulation, must be determined before the results are clinically applicable.
为了将麻醉诱导期间的脑电图（EEG）变化与意识水平相关联，在使用安氟醚以及安氟醚 - 笑气 - 氧气进行麻醉诱导期间，进行了四通道矢状旁脑电图记录。脑电图采用功率谱分析进行量化。在所有麻醉诱导过程中均发现脑电图有显著变化；然而，只有在遗忘症出现时变化的发生率才有显著意义（20名受试者中有15名，P = 0.04）。此时脑电图变化的性质具有药物特异性（卡方检验P＜0.05），安氟醚组出现高频变化，而笑气 - 安氟醚组以8 - 12Hz活动中的振幅变化为主。未发现前头部优势可作为遗忘症或无反应性的相关因素。识别此类脑电图变化可能对评估麻醉深度有价值，但在结果可临床应用之前，必须确定其他影响因素，如脑电图对手术刺激的反应。
