Fidder Hester, Veenhuizen Ruth B, Gerridzen Ineke J, van Wieringen Wessel N, Smalbrugge Martin, Hertogh Cees M P M, van Loon Anouk M
Department of Medicine for Older People, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, De Boelelaan 1109, 1081 HV Amsterdam, The Netherlands.
Atlant, Nursing Home Markenhof, Korsakoff Centre of Expertise, Kuiltjesweg 1, 7361 TC Beekbergen, The Netherlands.
J Clin Med. 2023 Apr 26;12(9):3139. doi: 10.3390/jcm12093139.
Impaired awareness of one's own functioning is highly common in people with Korsakoff's syndrome (KS). However, it is currently unclear how awareness relates to impairments in daily functioning and quality of life (QoL).
We assessed how impaired awareness relates to cognitive, behavioral, physical, and social functioning and QoL by applying a network analysis. We used cross-sectional data from 215 patients with KS or other severe alcohol-related cognitive deficits living in Dutch long-term care facilities (LTCFs).
Apathy has the most central position in the network. Higher apathy scores relate positively to reduced cognition and to a greater decline in activities of daily living and negatively to social participation and the use of antipsychotic drugs. Impaired awareness is also a central node. It is positively related to a higher perceived QoL, reduced cognition and apathy, and negatively to social participation and length of stay in the LTCF. Mediated through apathy and social participation, impaired awareness is indirectly related to other neuropsychiatric symptoms.
Impaired awareness is closely related to other domains of daily functioning and QoL of people with KS or other severe alcohol-related cognitive deficits living in LTCFs. Apathy plays a central role. Network analysis offers interesting insights to evaluate the interconnection of different symptoms and impairments in brain disorders such as KS.
在柯萨科夫综合征（KS）患者中，对自身功能的认知受损非常常见。然而，目前尚不清楚这种认知与日常功能障碍和生活质量（QoL）之间的关系。
我们通过应用网络分析来评估认知受损与认知、行为、身体和社会功能以及生活质量之间的关系。我们使用了来自215名居住在荷兰长期护理机构（LTCF）的KS患者或其他严重酒精相关认知缺陷患者的横断面数据。
冷漠在网络中处于最核心的位置。较高的冷漠得分与认知能力下降以及日常生活活动能力的更大下降呈正相关，与社会参与和抗精神病药物的使用呈负相关。认知受损也是一个核心节点。它与较高的生活质量感知、认知能力下降和冷漠呈正相关，与社会参与和在长期护理机构中的停留时间呈负相关。通过冷漠和社会参与介导，认知受损与其他神经精神症状间接相关。
认知受损与居住在长期护理机构中的KS患者或其他严重酒精相关认知缺陷患者的日常功能和生活质量的其他领域密切相关。冷漠起着核心作用。网络分析为评估诸如KS等脑部疾病中不同症状和损伤的相互联系提供了有趣的见解。
