Kim Kain, Marvil Charles, Adhyaru Bhavin B
Division of General Internal Medicine, Department of Medicine Emory University School of Medicine Atlanta Georgia United States.
Clin Case Rep. 2023 May 9;11(5):e7330. doi: 10.1002/ccr3.7330. eCollection 2023 May.
By reporting this case, we hope to emphasize the importance of maintaining a high index of clinical suspicion for the early recognition of RS3PE in patients presenting with atypical symptoms of PMR and underlying history of malignancy.
Remitting seronegative symmetrical synovitis with pitting edema is a rare rheumatic syndrome of unknown etiology. It shares qualities with many other common rheumatological disorders such as rheumatoid arthritis and polymyalgia rheumatica, making diagnosis especially challenging. RS3PE has been speculated to be a paraneoplastic syndrome, and those cases associated with underlying malignancy have shown to respond poorly to conventional treatment. Therefore, it is advisable to routinely screen patients with malignancy and presenting with RS3PE for cancer recurrence, even if in remission.
通过报告该病例，我们希望强调对于患有巨细胞动脉炎非典型症状且有恶性肿瘤病史的患者，保持高度临床怀疑指数以早期识别缓解性血清阴性对称性滑膜炎伴凹陷性水肿（RS3PE）的重要性。
缓解性血清阴性对称性滑膜炎伴凹陷性水肿是一种病因不明的罕见风湿综合征。它与许多其他常见的风湿性疾病如类风湿关节炎和巨细胞动脉炎有共同特征，这使得诊断极具挑战性。RS3PE被推测为一种副肿瘤综合征，与潜在恶性肿瘤相关的病例对传统治疗反应不佳。因此，即使处于缓解期，对于患有RS3PE的恶性肿瘤患者，常规筛查癌症复发也是可取的。
